Description

5-Fluoro-2-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline is a high-purity, advanced pharmaceutical intermediate featuring a pinacol boronate ester group, making it a critical building block for modern synthetic chemistry. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly those focused on creating novel active ingredients for drugs and crop protection agents. The CAS number for this compound is provided separately in the basic information below.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing fluorinated and biaryl motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific fluorinated aromatic structures.
• Material Science Research: Serves as a monomer or building block for creating novel organic electronic materials, such as those used in OLEDs and organic semiconductors.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester group is specifically designed for palladium-catalyzed cross-coupling with aryl halides, enabling efficient carbon-carbon bond formation.
• Medicinal Chemistry & Drug Discovery: Facilitates rapid parallel synthesis and library generation for high-throughput screening in early-stage drug discovery programs.
• Ligand and Catalyst Development: Can be utilized to synthesize novel bidentate or tridentate ligands for catalytic systems.

Basic Information

Product Name	5-Fluoro-2-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline
CAS No.	1227210-37-8
Molecular Formula	C13H19BFNO2
Molecular Weight	251.11 g/mol
Synonyms	3-Amino-4-fluoro-6-methylphenylboronic acid pinacol ester; (3-Amino-4-fluoro-6-methylphenyl)boronic acid pinacol ester; 5-Fluoro-2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine; 2-Methyl-5-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline; 1227210-37-8; Boronic acid, B-(3-amino-4-fluoro-6-methylphenyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Every batch of 5-Fluoro-2-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and purity. Our products are developed to meet the exacting standards required for pharmaceutical R&D and scale-up. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, GC, NMR, and MS is provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Optimal storage temperature is between 2°C and 8°C (refrigerated) to maximize shelf life and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.