Description

3-(2-Fluorophenyl)-2,2-Dimethylpropanoic Acid is a high-purity fluorinated organic building block of significant interest in advanced chemical synthesis. This compound serves as a critical intermediate for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique sterically hindered structure and fluorine atom impart desirable metabolic stability and bioavailability. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries engaged in cutting-edge R&D and scale-up production.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, leveraging the fluorine moiety for enhanced activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced organic materials with specific optical or electronic properties.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses serving the pharmaceutical and biotechnology sectors.
• Academic & Industrial R&D: Utilized in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.

Basic Information

Product Name	3-(2-Fluorophenyl)-2,2-Dimethylpropanoic Acid
CAS No.	1226161-12-1
Molecular Formula	C11H13FO2
Molecular Weight	196.22 g/mol
Synonyms	2-Fluoro-α,α-dimethylbenzenepropanoic Acid; 2-(2-Fluorophenyl)-2-methylpropanoic Acid; 3-(2-Fluorophenyl)-2,2-dimethylpropionic Acid; α,α-Dimethyl-2-fluorohydrocinnamic Acid; 2,2-Dimethyl-3-(2-fluorophenyl)propanoic Acid; 2-Fluoro-α,α-dimethylhydrocinnamic Acid; Benzenepropanoic acid, 2-fluoro-α,α-dimethyl-; (2-Fluorophenyl)-2,2-dimethylacetic Acid derivative
EINECS	Contact for details

Quality Control

Our 3-(2-Fluorophenyl)-2,2-Dimethylpropanoic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, confirming compliance with client specifications and relevant industry guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.