Description

4-(Difluoromethoxy)-1,2-Difluoro-Benzene is a high-value fluorinated aromatic building block, essential for introducing the difluoromethoxy and difluoroaryl motifs into advanced molecular architectures. Its unique structure makes it a critical intermediate in the synthesis of active pharmaceutical ingredients (APIs) and agrochemicals, where fluorine substitution is used to modulate bioavailability, metabolic stability, and binding affinity. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for creating next-generation compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in areas like kinase inhibitors and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides with enhanced efficacy and environmental profile.
• Liquid Crystal Materials: Serves as a precursor for fluorinated components in liquid crystal displays (LCDs) to improve dielectric anisotropy and stability.
• Organic Electronics: Employed in the research and development of organic semiconductors and electro-optical materials.
• Fluorinated Polymer Research: Acts as a monomer or modifier in the synthesis of specialty polymers with unique surface properties and chemical resistance.
• Chemical Research & Development: A versatile reagent for exploring new fluorination methodologies and creating complex fluorinated molecules for various applications.

Basic Information

Item	Detail
Product Name	4-(Difluoromethoxy)-1,2-Difluoro-Benzene
CAS No.	1226153-51-0
Molecular Formula	C7H4F4O
Molecular Weight	180.10 g/mol
Synonyms	1,2-Difluoro-4-(difluoromethoxy)benzene; 4-(Difluoromethoxy)-1,2-difluorobenzene; 1,2-Difluoro-4-(difluoromethoxy)benzene; Benzene, 1,2-difluoro-4-(difluoromethoxy)-; Difluoromethoxy-difluorobenzene; DFMOB (abbreviation)
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethoxy)-1,2-Difluoro-Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles where applicable, supporting our customers' regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.