Description

Acamprosate-D3 Calcium is a high-purity, isotopically labeled internal standard critical for ensuring analytical accuracy and reliability in quantitative bioanalysis. This deuterated compound is specifically designed for use in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) applications, where it compensates for matrix effects and instrument variability. It is an essential tool for pharmaceutical researchers, clinical laboratories, and contract research organizations (CROs) conducting pharmacokinetic studies, therapeutic drug monitoring, and metabolism research for acamprosate.

Application

• Quantitative Bioanalysis: Serves as a stable isotope-labeled internal standard for the precise quantification of acamprosate in biological matrices (plasma, serum, urine) using LC-MS/MS or GC-MS.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate measurement of drug concentration-time profiles to determine absorption, distribution, metabolism, and excretion (ADME) parameters.
• Therapeutic Drug Monitoring (TDM): Supports clinical assays to monitor patient acamprosate levels, ensuring therapeutic efficacy and safety in the treatment of alcohol dependence.
• Metabolite Identification and Profiling: Aids in distinguishing drug-derived metabolites from endogenous compounds in complex biological samples.
• Method Development and Validation: Used as a critical component in developing, optimizing, and validating robust analytical methods according to FDA, EMA, or ICH guidelines.
• Quality Control in Manufacturing: Can be utilized in impurity profiling and assay validation of acamprosate active pharmaceutical ingredient (API) and finished dosage forms.

Basic Information

Product Name	Acamprosate-D3 Calcium
CAS No.	1225580-94-8
Molecular Formula	C10H17D3CaN2O8S2
Molecular Weight	403.51 g/mol (for monoisotopic mass)
Synonyms	Calcium bis(N-acetyl-DL-homotaurinate)-D3; Acamprosate Calcium-d3; 3-Acetamidopropane-1,1,1-d3-sulfonic Acid Calcium Salt; N-Acetylhomotaurine Calcium Salt-d3; Calcium Acetylhomotaurinate-d3; Campral-d3 (labeled analog); AOTA Calcium Salt-d3
EINECS	Contact for details

Quality Control

Every batch of Acamprosate-D3 Calcium is manufactured and analyzed under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) that detail purity, isotopic enrichment, and impurity profiles, ensuring traceability and compliance with research and regulatory standards. Our products undergo rigorous quality testing, including advanced spectroscopic and chromatographic methods, to guarantee they meet the exacting requirements for use as certified reference materials in regulated bioanalysis.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment	≥98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.