Description

Acamprosate-D12 Calcium (Dipropyl-D12) is a high-purity, stable isotope-labeled internal standard essential for precise quantitative analysis in modern bioanalytical and pharmacokinetic studies. This deuterated compound provides unmatched accuracy by eliminating interference from endogenous compounds and matrix effects during mass spectrometry. It is a critical tool for researchers and quality control laboratories in the pharmaceutical and contract research organization (CRO) sectors who require reliable data for method development, validation, and regulatory submissions.

Application

• Quantitative Bioanalysis: Serves as an internal standard in LC-MS/MS and GC-MS methods for the accurate measurement of Acamprosate and its metabolites in biological matrices like plasma, serum, and urine.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and pre-clinical research.
• Drug Metabolism Research: Used to study metabolic pathways and identify metabolites, ensuring comprehensive understanding of a drug's fate in the body.
• Method Development & Validation: Critical for developing robust, reproducible, and GLP-compliant analytical methods in pharmaceutical R&D and quality control.
• Forensic Toxicology: Supports accurate quantification in forensic analyses where precise measurement of drug levels is legally required.
• Reference Material Production: Used to prepare certified reference materials (CRMs) and quality control samples for laboratory proficiency testing.

Basic Information

Product Name	Acamprosate-D12 Calcium (Dipropyl-D12)
CAS No.	1225580-91-5
Molecular Formula	C10D12CaN2O8S2 • xH2O
Molecular Weight	Contact for details
Synonyms	Calcium Acamprosate-D12; 3-Acetamidopropane-1-sulfonic Acid-D12 Calcium Salt; Acamprosate Calcium-d12; N-Acetylhomotaurine-d12 Calcium Salt; Campral-d12; Calcium bis(3-(acetylamino)propane-1-sulfonate)-d12; 3-Acetamidopropanesulfonic Acid-d12 Calcium Salt; AOTA-d12 Calcium Salt
EINECS	Contact for details

Quality Control

Every batch of Acamprosate-D12 Calcium is manufactured and analyzed under strict quality management systems to ensure the highest isotopic purity and chemical integrity. Our products undergo rigorous quality testing, including advanced spectroscopic and chromatographic techniques, to ensure compliance with research and analytical standards. Certificates of Analysis (COA) detailing isotopic enrichment, chemical purity, and analytical results are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 20 ppm
Water Content (KF)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.