Description

Cefiderocol is a novel siderophore cephalosporin antibiotic with a unique mechanism of action, combining potent antibacterial activity with the ability to circumvent common resistance pathways. This compound is of critical importance for addressing serious infections caused by multidrug-resistant Gram-negative pathogens, including carbapenem-resistant strains. It is essential for pharmaceutical R&D, clinical microbiology, and the development of next-generation antimicrobial therapies targeting a global health threat.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the active component in injectable antibiotic formulations for hospital use.
• Antimicrobial Research & Development: A key reference standard and intermediate in the discovery of new antibiotics and combination therapies.
• Clinical Microbiology & Diagnostics: Used as a control agent in susceptibility testing and studies of bacterial resistance mechanisms.
• Academic & Institutional Research: Fundamental research on siderophore-conjugated antibiotics and bacterial iron transport systems.
• Regulatory Compliance & Quality Control: Serves as a certified reference material for analytical method development and validation in QC laboratories.

Basic Information

Product Name	Cefiderocol
CAS No.	1225208-94-5
Molecular Formula	C28H31ClFeN8O7S2
Molecular Weight	731.03 g/mol
Synonyms	S-649266; (6R,7R)-7-[[(2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-[[(1-carboxy-1-methylethoxy)imino]acetyl]amino]-3-[[1-[2-(2,3-dihydroxybenzamido)ethyl]pyrrolidin-1-ium-1-yl]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate; Iron complex of S-649266; Fetroja (Brand Name); Cefiderocol sulfate tosylate; S-649266CL2
EINECS	Contact for details

Quality Control

Our Cefiderocol is manufactured and tested under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, identification by IR and NMR, and stringent controls for related substances and residual solvents. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to ensure traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to light yellow powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.