Description

(1S,2S)-N,n-Bis[2-(Di-p-Tolylphosphino)Benzyl]Cyclohexane-1,2-Diamine is a sophisticated chiral ligand belonging to the Josiphos family, renowned for its exceptional performance in asymmetric catalysis. Its core value lies in enabling highly enantioselective transformations, which are critical for producing single-isomer active pharmaceutical ingredients (APIs) and fine chemicals with superior purity and efficacy. This ligand is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries who require precise stereochemical control in hydrogenation, cross-coupling, and other transition metal-catalyzed reactions.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in API synthesis.
• Pharmaceutical Intermediate Manufacturing: Critical for producing chiral building blocks for cardiovascular, central nervous system (CNS), and antiviral drugs.
• Agrochemical Synthesis: Used in the production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Cross-Coupling Reactions: Facilitates asymmetric C-C and C-X bond-forming reactions with high stereoselectivity.
• Academic & Industrial R&D: A valuable tool for developing new catalytic methodologies and exploring novel synthetic routes.
• Fine Chemical Production: Enables the manufacture of high-value chiral flavors, fragrances, and advanced materials.

Basic Information

Product Name	(1S,2S)-N,n-Bis[2-(Di-p-Tolylphosphino)Benzyl]Cyclohexane-1,2-Diamine
CAS No.	1224727-08-5
Molecular Formula	C52H58N2P2
Molecular Weight	773.00 g/mol
Synonyms	(1S,2S)-(-)-1,2-Bis[(2-(Di-p-tolylphosphino)benzyl)amino]cyclohexane; Josiphos SL-J009-1; (S,S)-JOSIPHOS; (1S,2S)-JOSIPHOS Ligand; (S,S)-(-)-1,2-Bis[(2-(Di-p-tolylphosphino)benzyl)amino]cyclohexane; (1S,2S)-Bis[(2-(Di-p-tolylphosphino)benzyl)amino]cyclohexane; (S,S)-Cyclohexane-1,2-diamine, N,N-bis[2-(di-p-tolylphosphino)benzyl]-
EINECS	Contact for details

Quality Control

Our production of (1S,2S)-N,n-Bis[2-(Di-p-Tolylphosphino)Benzyl]Cyclohexane-1,2-Diamine adheres to stringent quality protocols to ensure batch-to-batch consistency and high catalytic performance. Each lot is characterized by advanced analytical techniques, including NMR, HPLC, and chiral analysis, to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to prevent oxidation and degradation. Keep the container in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to yellow powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Solubility	Soluble in common organic solvents (e.g., Toluene, DCM, THF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.