Description

Latanoprost (Free Acid)-D4 is a high-purity, deuterium-labeled internal standard critical for precise quantitative analysis in pharmaceutical research and development. This stable isotope-labeled compound is essential for ensuring accuracy and reliability in mass spectrometry-based bioanalytical methods. It is primarily used by analytical chemists and researchers in pharmaceutical companies and contract research organizations (CROs) for the development and validation of assays for Latanoprost and related prostaglandin analogs.

Application

• Internal Standard for LC-MS/MS: Serves as a critical reference compound in Liquid Chromatography-Tandem Mass Spectrometry for the quantification of Latanoprost in biological matrices (plasma, serum, ocular tissues).
• Pharmacokinetic and Bioavailability Studies: Enables accurate measurement of drug concentration over time, supporting ADME (Absorption, Distribution, Metabolism, Excretion) studies.
• Method Development and Validation: Used as a deuterated standard to establish selective, sensitive, and robust analytical methods compliant with ICH and FDA guidelines.
• Quality Control in Manufacturing: Supports impurity profiling and assay verification during the production of Latanoprost active pharmaceutical ingredient (API) and finished drug products.
• Metabolite Identification: Aids in the detection and structural elucidation of Latanoprost metabolites in in vitro and in vivo studies.

Basic Information

Item	Details
Product Name	Latanoprost (Free Acid)-D4
CAS No.	1224443-47-3
Molecular Formula	C26H37D4NO6
Molecular Weight	459.62 g/mol (approx.)
Synonyms	Latanoprost-d4 (Free Acid); (5Z,9α,11α,13E,15S)-9,11,15-Trihydroxy-17-phenyl-18,19,20-trinor-5,13-prostadienoic Acid-d4; 13,14-Didehydro-17-phenyl-18,19,20-trinor-PGF2α-d4; Prostaglandin F2α analog-d4; Deuterated Latanoprost Acid; Latanoprost Acid-d4; Latanoprost-d4 Acid; Xalatan-d4 (Free Acid)
EINECS	Contact for details

Quality Control

Our Latanoprost (Free Acid)-D4 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for identity, assay, isotopic enrichment, and purity by HPLC. We support compliance with cGMP and ISO 9001 standards for research materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.