Description

(E)-3-(4-(Hydrazinecarbonyl)Phenyl)-n-Hydroxyacrylamide Hydrochloride is a specialized organic compound with a distinct molecular structure featuring a hydroxamic acid moiety and a hydrazide group. This compound is of significant interest in pharmaceutical research and development, particularly as a potential intermediate or active component in the synthesis of novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, specifically targeting enzyme inhibition pathways. The precise molecular architecture offers a valuable scaffold for medicinal chemists exploring treatments for conditions where metalloenzyme modulation is critical.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of targeted drug candidates, especially histone deacetylase (HDAC) inhibitors.
• Biochemical Research: Used as a reference standard or probe in enzymatic studies to investigate inhibition mechanisms and binding affinities.
• Medicinal Chemistry: Provides a versatile scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of new chemical entities.
• Preclinical Development: Employed in the early-stage development of potential therapeutics for oncology, neurology, and inflammatory diseases.
• Chemical Biology: Utilized as a tool compound to study cellular processes involving zinc-dependent enzymes.

Basic Information

Item	Details
Product Name	(E)-3-(4-(Hydrazinecarbonyl)Phenyl)-n-Hydroxyacrylamide Hydrochloride
CAS No.	1223593-75-6
Molecular Formula	C10H12N3O3 • HCl
Molecular Weight	257.68 g/mol (Free base: 222.22 g/mol)
Synonyms	N-Hydroxy-3-[4-(hydrazinecarbonyl)phenyl]prop-2-enamide hydrochloride; (E)-N-Hydroxy-3-(4-(hydrazinecarbonyl)phenyl)acrylamide HCl; 3-(4-Hydrazinylcarbonylphenyl)-N-hydroxyacrylamide hydrochloride; Hydroxamic acid derivative CAS 1223593-75-6; HDAC inhibitor intermediate; Prop-2-enamide derivative
EINECS	Contact for details

Quality Control

Every batch of (E)-3-(4-(Hydrazinecarbonyl)Phenyl)-n-Hydroxyacrylamide Hydrochloride is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency meet the exacting standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.