Description

(S)-2-[(Diphenylphosphino)Methyl]Pyrrolidinium Tetrafluoroborate is a chiral, non-racemic organophosphorus salt that serves as a versatile precursor to P-stereogenic ligands and catalysts. This compound matters for its role in enabling highly enantioselective transformations, which are critical for the efficient synthesis of single-enantiomer pharmaceuticals and fine chemicals. Industries requiring advanced asymmetric synthesis, including pharmaceutical R&D, agrochemical manufacturing, and specialty chemical production, are the primary users of this high-value intermediate.

Application

• Precursor for the synthesis of chiral phosphine-phosphoramidite and phosphine-phosphite ligands.
• Catalyst component in asymmetric hydrogenation reactions for pharmaceutical intermediates.
• Key building block in the development of P-chiral auxiliaries for stereoselective carbon-carbon bond formation.
• Use in asymmetric hydroformylation and hydroboration processes in fine chemical synthesis.
• Research and development of novel organocatalysts and transition metal complexes.
• Production of high-purity reference standards for analytical method development.

Basic Information

Product Name	(S)-2-[(Diphenylphosphino)Methyl]Pyrrolidinium Tetrafluoroborate
CAS No.	1222630-36-5
Molecular Formula	C18H23BF4NP
Molecular Weight	371.16 g/mol
Synonyms	(S)-2-[(Diphenylphosphino)methyl]pyrrolidin-1-ium tetrafluoroborate; (S)-2-(Diphenylphosphanylmethyl)pyrrolidin-1-ium tetrafluoroborate; (S)-2-[(Diphenylphosphino)methyl]pyrrolidine tetrafluoroborate salt; (S)-Pyrrolidinium, 2-[(diphenylphosphino)methyl]-, tetrafluoroborate(1-); P-Chiral pyrrolidinium salt; Precursor to (S)-Pyrphos; Ligand precursor 1222630-36-5
EINECS	Contact for details

Quality Control

Our (S)-2-[(Diphenylphosphino)Methyl]Pyrrolidinium Tetrafluoroborate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC and NMR spectroscopy, to ensure it meets the stringent requirements for asymmetric synthesis applications. A detailed Certificate of Analysis (COA) providing batch-specific data for identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C under an inert atmosphere (e.g., nitrogen or argon) due to its sensitivity to moisture and oxidation. Keep away from strong acids and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.