Description

Fmoc-L-Homopro(4-Oxo) CAS NO 1221793-43-6 is a specialized, high-purity Fmoc-protected amino acid derivative designed for advanced peptide synthesis. This compound is critical for introducing the unique homoproline (4-oxo) moiety into peptide chains, enabling the research and development of novel bioactive molecules with modified structural and functional properties. It is an essential building block for pharmaceutical researchers, medicinal chemists, and biotech companies engaged in drug discovery, particularly for creating peptide-based therapeutics and probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the automated synthesis of complex peptides containing the homoproline scaffold.
• Medicinal Chemistry & Drug Discovery: Used in the research and development of new therapeutic peptides targeting various diseases, where the 4-oxo homoproline residue can influence bioavailability and receptor binding.
• Peptidomimetic Design: Facilitates the creation of peptidomimetics—molecules that mimic peptides—to enhance metabolic stability and pharmacological properties.
• Bioconjugation and Probe Development: Serves as a precursor for labeling peptides with fluorescent tags or other functional groups for diagnostic and research applications.
• Academic and Industrial R&D: A vital reagent in laboratories focused on organic synthesis, chemical biology, and protein engineering.

Basic Information

Product Name	Fmoc-L-Homopro(4-Oxo)
CAS No.	1221793-43-6
Molecular Formula	C21H19NO5
Molecular Weight	365.38 g/mol
Synonyms	Fmoc-L-homoproline(4-one); Fmoc-4-oxo-L-homoproline; (S)-1-((((9H-Fluoren-9-yl)methoxy)carbonyl)-4-oxopyrrolidine-2-carboxylic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-oxo-L-homoproline; Fmoc-4-keto-L-homoproline; Nα-Fmoc-4-oxo-L-homoproline; Fmoc-Hpr(4-Oxo)-OH; Fmoc-L-4-oxohomoproline
EINECS	Contact for details

Quality Control

Our Fmoc-L-Homopro(4-Oxo) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.