Description

(Rp)-1-[(S)-1-(Di-tert-Butylphosphino)Ethyl]-2-[(S)-Phenylphosphinoyl]Ferrocene CAS NO 1221746-66-2 is a highly sophisticated, chiral ferrocenyl phosphine-phosphinite ligand, distinguished by its planar chirality and precise stereochemistry. This compound is a critical enabler for asymmetric catalysis, offering exceptional control over reaction stereoselectivity in the synthesis of complex chiral molecules. It is an essential tool for R&D and production chemists in the pharmaceutical and fine chemical industries, where creating single-enantiomer products is paramount.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, ketones, and imines, crucial for producing chiral pharmaceutical intermediates.
• Asymmetric C-C Bond Formation: Catalyzes key reactions such as cross-coupling, allylic alkylation, and hydroformylation with high enantiomeric excess (ee).
• Pharmaceutical Intermediate Synthesis: Enables the efficient and scalable production of single-enantiomer active pharmaceutical ingredients (APIs) for drugs targeting CNS, cardiovascular, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of chiral herbicides, fungicides, and pesticides with improved efficacy and environmental profiles.
• Advanced Material Research: Facilitates the synthesis of chiral polymers and liquid crystals with unique optical and electronic properties.
• Academic & Process Chemistry: A valuable reagent for methodology development and optimizing catalytic processes in research laboratories and pilot plants.

Basic Information

Item	Details
Product Name	(Rp)-1-[(S)-1-(Di-tert-Butylphosphino)Ethyl]-2-[(S)-Phenylphosphinoyl]Ferrocene
CAS No.	1221746-66-2
Molecular Formula	C32H40FeO2P2
Molecular Weight	558.45 g/mol
Synonyms	(Rp,S,S)-Josiphos SL-J009-1; (Rp)-1-[(S)-1-(Di-tert-butylphosphino)ethyl]-2-[(S)-diphenylphosphino]ferrocene oxide; Josiphos SL-J009-1 ligand; Chiral Ferrocenyl Josiphos-type ligand; (Rp,S,S)-1-[1-(Di-tert-butylphosphanyl)ethyl]-2-(phenylphosphanyl)ferrocene 2-oxide; Asymmetric hydrogenation ligand J009-1
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands is produced and tested under strict quality control protocols to ensure consistent high performance in sensitive catalytic applications. We provide comprehensive Certificates of Analysis (COA) detailing purity, enantiomeric excess, and identity confirmation. Our quality system is designed to support cGMP and ISO standards for traceability and reliability, ensuring seamless integration into regulated production workflows.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized and moisture-sensitive; handling should be performed in a controlled, dry environment.

Specification

Item	Specification
Appearance	Orange to red powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.