Description

(Sp)-1-[(R)-1-(Di-tert-Butylphosphino)Ethyl]-2-[(R)-Phenylphosphinoyl]Ferrocene is a highly specialized, chiral ferrocenyl phosphine-phosphinite ligand, a cornerstone in modern asymmetric catalysis. Its value lies in its ability to induce exceptional enantioselectivity and high catalytic activity in a range of transition-metal-catalyzed reactions, enabling the efficient synthesis of single-enantiomer compounds. This ligand is essential for research and process chemists in the pharmaceutical, agrochemical, and fine chemical industries, where the production of optically pure intermediates and active ingredients is critical.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective hydrogenation of prochiral olefins, ketones, and imines, crucial for producing chiral alcohols and amines in pharmaceutical synthesis.
• Asymmetric C-C Bond Formation: Employed in cross-coupling reactions, allylic substitutions, and other C-C bond-forming processes to create complex, chiral molecular architectures.
• Pharmaceutical Intermediate Synthesis: Used in the development and scalable production of active pharmaceutical ingredients (APIs) requiring high optical purity.
• Agrochemical Manufacturing: Facilitates the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical and Flavor/Fragrance Production: Enables the cost-effective creation of high-value chiral compounds for specialty applications.
• Academic and Industrial R&D: A vital tool for methodology development and exploring new catalytic transformations in both academic and corporate research laboratories.

Basic Information

Product Name	(Sp)-1-[(R)-1-(Di-tert-Butylphosphino)Ethyl]-2-[(R)-Phenylphosphinoyl]Ferrocene
CAS No.	1221746-56-0
Molecular Formula	C28H38FeO2P2
Molecular Weight	508.39 g/mol
Synonyms	(RFc,SC,RP)-1-[(R)-1-(Di-tert-butylphosphino)ethyl]-2-[(R)-phenylphosphinoyl]ferrocene; Josiphos SL-J009-1; (RFc,SC,RP)-1-[(R)-1-(Di-tert-butylphosphino)ethyl]-2-[(R)-diphenylphosphino]ferrocene oxide; (RFc,SC,RP)-1-[(R)-1-(Bis(1,1-dimethylethyl)phosphino)ethyl]-2-[(R)-phenylphosphinyl]ferrocene; Chiral Ferrocenyl Phosphine-Phosphinite Ligand; SL-J009-1
EINECS	Contact for details

Quality Control

Every batch of (Sp)-1-[(R)-1-(Di-tert-Butylphosphino)Ethyl]-2-[(R)-Phenylphosphinoyl]Ferrocene is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the ligand meets the high standards required for sensitive asymmetric catalysis. A detailed Certificate of Analysis (COA), including results for chiral purity, chemical purity, and metal content, is supplied with each shipment to guarantee reproducible performance in your applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to minimize oxidation and ensure long-term stability. The container should be kept in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	Orange to red-brown solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Solubility	Soluble in common organic solvents (DCM, THF, Toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.