Description

3,4-Difluoro-5-Hydroxyphenylboronic Acid, Pinacol Ester is a high-purity, protected boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the precise construction of complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds in the synthesis of biaryl and heterobiaryl structures, which are common motifs in drug discovery.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs), particularly those containing difluorophenol and arylboronate functional groups.
• Agrochemical Synthesis: Employed in creating advanced herbicides, fungicides, and insecticides that require specific fluorinated aromatic components.
• Material Science Research: Acts as a monomer or precursor in the development of organic electronic materials, such as polymers for OLEDs or sensors.
• Ligand and Catalyst Development: Useful for synthesizing novel bidentate or tridentate ligands used in catalysis.
• Chemical Biology Probes: Facilitates the creation of tagged molecules for studying biological processes and protein interactions.

Basic Information

Product Name	3,4-Difluoro-5-Hydroxyphenylboronic Acid, Pinacol Ester
CAS No.	1220219-43-1
Molecular Formula	C12H15BF2O3
Molecular Weight	256.06 g/mol
Synonyms	5-Hydroxy-3,4-difluorophenylboronic acid pinacol ester; (5-Hydroxy-3,4-difluorophenyl)boronic acid pinacol ester; 3,4-Difluoro-5-hydroxybenzeneboronic acid pinacol ester; 2-(3,4-Difluoro-5-hydroxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol (3,4-difluoro-5-hydroxyphenyl)boronate; B-(3,4-Difluoro-5-hydroxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 3,4-Difluoro-5-Hydroxyphenylboronic Acid, Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and scale-up. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems support development from non-GMP research to GMP clinical trial material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.