Description

Benzonitrile, 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-(Trifluoromethyl)- is a high-value, multi-functional boronic ester derivative, serving as a critical synthetic intermediate in modern organic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone of pharmaceutical and advanced materials development. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and organic electronics industries who require reliable, high-purity building blocks for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing trifluoromethyl and aromatic nitrile motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides where the benzonitrile core is a common bioactive scaffold.
• Material Science: Serves as a monomer or precursor for advanced polymers, liquid crystals, and organic semiconductors (OLEDs, OFETs) due to its electron-withdrawing groups.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura cross-coupling to introduce the 2-(trifluoromethyl)-5-cyanophenyl moiety into target molecules.
• Chemical Research & Development: A versatile reagent for medicinal chemistry, process R&D, and exploring new synthetic methodologies in academic and industrial laboratories.
• Ligand and Catalyst Preparation: Can be utilized to synthesize novel bidentate or monodentate ligands for catalysis.

Basic Information

Product Name	Benzonitrile, 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-(Trifluoromethyl)-
CAS No.	1220219-14-6
Molecular Formula	C₁₄H₁₅BF₃NO₂
Molecular Weight	297.08 g/mol
Synonyms	2-(Trifluoromethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile; [5-Cyano-2-(trifluoromethyl)phenyl]boronic acid pinacol ester; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)benzonitrile; 2-Trifluoromethyl-5-cyanophenylboronic acid pinacol ester; Pinacol [5-cyano-2-(trifluoromethyl)phenyl]boronate
EINECS	Contact for details

Quality Control

Our Benzonitrile, 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-(Trifluoromethyl)- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive applications. All products undergo rigorous analytical testing, including NMR, HPLC, and GC-MS, to verify identity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.