Description

Citalopram-D4 CAS NO 1219908-84-5 is a deuterated internal standard of the widely prescribed antidepressant Citalopram, specifically labeled with four deuterium atoms. This high-purity reference material is essential for ensuring the accuracy and reliability of quantitative analysis in complex biological matrices. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities for applications in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and quality control.

Application

• Bioanalytical Method Development and Validation as a stable isotope-labeled internal standard for Liquid Chromatography-Mass Spectrometry (LC-MS/MS).
• Pharmacokinetic (PK) and Drug Metabolism Studies to accurately quantify Citalopram and its metabolites in plasma, serum, and other biological fluids.
• Clinical Research and Therapeutic Drug Monitoring (TDM) to support studies on drug efficacy, safety, and patient adherence.
• Forensic and Toxicology Analysis for the precise identification and quantification of Citalopram in forensic investigations.
• Pharmaceutical Quality Control in the development and manufacturing of generic or novel antidepressant formulations.
• Regulatory Submissions to provide validated analytical data required by agencies like the FDA and EMA.

Basic Information

Product Name	Citalopram-D4
CAS No.	1219908-84-5
Molecular Formula	C20H17D4FN2O
Molecular Weight	328.41 g/mol
Synonyms	1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile-D4; Citalopram-d4; (+/-)-Citalopram-D4; 1,3-Dihydro-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-5-isobenzofurancarbonitrile-D4; Citalopram (D4, major); Celexa-D4 (labeled)
EINECS	Contact for details

Quality Control

Our Citalopram-D4 is manufactured under strict quality management systems to ensure the highest standards of purity and isotopic enrichment required for analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for identity, purity (by HPLC), chemical purity, isotopic purity (D-enrichment), and residual solvents. We support compliance with ICH Q2(R1) guidelines for analytical method validation.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or CoA. This material is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider storing under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥98.0%
Chemical Purity (HPLC)	≥99.0%
Isotopic Purity (D-enrichment)	≥98 atom % D
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.