Description

3-Aminomethyl-3-Fluoropiperidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a fluorinated piperidine scaffold. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel bioactive molecules with enhanced metabolic stability and binding affinity. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing new drug candidates, particularly in the areas of central nervous system (CNS) and oncology therapeutics.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting neurological receptors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore the impact of fluorination and amine functionalization on drug-like properties.
• Protease Inhibitor Development: Serves as a core scaffold for the development of inhibitors for various protease enzymes.
• Ligand Synthesis for Drug Discovery: Employed in creating sophisticated ligands for high-throughput screening and target validation.
• Fine Chemical Synthesis: Used in multi-step organic synthesis to introduce fluorinated, protected piperidine motifs into complex molecules.
• Pre-clinical Candidate Development: Integral in the synthesis of compounds for pharmacokinetic and toxicology studies during early-stage drug development.

Basic Information

Item	Details
Product Name	3-Aminomethyl-3-Fluoropiperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1219832-36-6
Molecular Formula	C12H23FN2O2
Molecular Weight	246.32 g/mol
Synonyms	tert-Butyl 3-(aminomethyl)-3-fluoropiperidine-1-carboxylate; 1-Boc-3-(aminomethyl)-3-fluoropiperidine; 3-Fluoro-3-(aminomethyl)piperidine-1-carboxylic acid tert-butyl ester; 3-(Aminomethyl)-3-fluoropiperidine-1-carboxylic acid tert-butyl ester; N-Boc-3-(aminomethyl)-3-fluoropiperidine; 1-(tert-Butoxycarbonyl)-3-(aminomethyl)-3-fluoropiperidine; 3-Fluoro-3-piperidinemethanamine, 1-(1,1-dimethylethyl) ester
EINECS	Contact for details

Quality Control

Our 3-Aminomethyl-3-Fluoropiperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical quality attributes are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.