Description

T-Boc-n-Amido-Peg4-Propargyl is a heterobifunctional polyethylene glycol (PEG) linker featuring a tert-butyloxycarbonyl (Boc)-protected amine and a terminal propargyl group. This compound is essential for creating stable, cleavable, and functionalized bioconjugates in advanced research and development. It is primarily utilized by scientists and manufacturers in the pharmaceutical, biotechnology, and materials science industries for applications in drug delivery, proteomics, and surface functionalization.

Application

• Bioconjugation and ADC Development: Used as a key linker for site-specific conjugation of cytotoxic drugs to antibodies in Antibody-Drug Conjugate (ADC) synthesis.
• Peptide and Protein Modification: Enables the PEGylation of peptides and proteins to enhance solubility, stability, and circulation half-life.
• Click Chemistry: The terminal propargyl group facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAC) for efficient and selective labeling of biomolecules.
• Polymer and Materials Science: Serves as a functional building block for synthesizing smart polymers, hydrogels, and functionalized surfaces.
• Diagnostic Reagents: Employed in the development of diagnostic assays and imaging probes through controlled conjugation strategies.
• Prodrug Synthesis: Facilitates the creation of prodrugs with controlled release mechanisms via the acid-labile Boc protecting group.

Basic Information

Product Name	T-Boc-n-Amido-Peg4-Propargyl
CAS No.	1219810-90-8
Molecular Formula	C23H41NO9
Molecular Weight	475.58 g/mol
Synonyms	1-Boc-1,13-diamino-4,7,10-trioxatridec-12-yn-13-one; 2,5,8,11-Tetraoxatetradec-13-yn-14-oic acid, 14-[[(1,1-dimethylethoxy)carbonyl]amino]-4,7,10-trioxa-13-azatetradec-1-yl ester; Boc-NH-PEG4-propargyl; tert-Butyl (17-oxo-4,7,10,13-tetraoxa-16-azaheptadec-1-yn-16-yl)carbamate; Propargyl-PEG4-Boc-amine; Boc-Amine-PEG4-Propargyl; N-Boc-1,13-diamino-4,7,10-trioxatridec-12-yn-13-one
EINECS	Contact for details

Quality Control

Our T-Boc-n-Amido-Peg4-Propargyl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and pharmaceutical-grade intermediates. Certificates of Analysis (COA) with detailed specifications from HPLC, NMR, and MS are provided to guarantee traceability and compliance with your project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.