Description

Hydroxyzine-D4 2Hcl is a deuterated internal standard of the antihistamine hydroxyzine, specifically labeled with four deuterium atoms. This high-purity reference material is critical for ensuring accurate and reliable quantification in analytical methods, particularly in pharmaceutical research and forensic toxicology. It is an essential tool for scientists and quality control laboratories requiring precise measurement of hydroxyzine and its metabolites.

Application

• Pharmaceutical Research & Development: Serves as a critical internal standard in method development and validation for bioanalytical studies of hydroxyzine.
• Clinical & Forensic Toxicology: Enables precise and accurate quantification of hydroxyzine in biological matrices (e.g., blood, plasma, urine) for therapeutic drug monitoring and forensic investigations.
• Metabolite Studies: Used in pharmacokinetic and metabolic pathway research to track and quantify hydroxyzine and its derivatives.
• Quality Control & Assurance: Essential for ensuring the accuracy of assay results in pharmaceutical manufacturing quality control laboratories.
• Regulatory Compliance Testing: Supports testing protocols required for regulatory submissions to agencies like the FDA and EMA.
• Stability-Indicating Methods: Used in stability testing of pharmaceutical formulations to accurately measure active pharmaceutical ingredient (API) degradation.

Basic Information

Product Name	Hydroxyzine-D4 2Hcl
CAS No.	1219805-91-0
Molecular Formula	C21H23D4ClN2O2•2HCl
Molecular Weight	447.85 g/mol
Synonyms	Hydroxyzine-d4 Dihydrochloride; 2-[2-[4-[(4-Chlorophenyl)(phenyl)methyl]piperazin-1-yl]ethoxy]ethanol-d4 Dihydrochloride; Atarax-d4 2HCl; Vistaril-d4 2HCl; (±)-Hydroxyzine-d4 Dihydrochloride; 1-(p-Chloro-α-phenylbenzyl)-4-[2-(2-hydroxyethoxy)ethyl]-piperazine-d4 Dihydrochloride
EINECS	Contact for details

Quality Control

Our Hydroxyzine-D4 2Hcl is manufactured under strict quality systems to ensure the highest standards of purity and isotopic enrichment required for analytical reference standards. Each batch undergoes comprehensive analysis, including HPLC, NMR, and MS, to confirm chemical and isotopic purity. A detailed Certificate of Analysis (COA) providing batch-specific data is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.