Description

4-(Methyl-D3-Amino)Butyric-2,2,3,3,4,4-D6 Acid Hcl is a high-purity, multi-deuterated isotopologue of 4-(Methylamino)butyric acid hydrochloride, a compound of significant interest in advanced research and development. This product matters because its specific deuterium labeling pattern provides exceptional utility as a stable isotope-labeled internal standard for precise quantitative analysis in mass spectrometry. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical chemistry specialists working on method development, pharmacokinetic studies, and metabolite identification.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering reference compound for the accurate quantification of its non-deuterated counterpart or related analytes in complex biological matrices like plasma, serum, and urine.
• Pharmaceutical Metabolism and Pharmacokinetics (DMPK) Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) for new chemical entities.
• Biomarker Research and Validation: Used in the development and validation of highly sensitive and specific analytical assays for endogenous metabolites or biomarkers.
• Deuterated Building Block: Acts as a specialized synthon for the synthesis of more complex, deuterium-labeled molecules for use in mechanistic studies or as potential deuterated drugs.
• Quality Control in API Manufacturing: Supports impurity profiling and assay validation for active pharmaceutical ingredients (APIs) where the parent compound is a key intermediate or related substance.
• Neurochemical Research: Potential tool in studies related to GABA (γ-aminobutyric acid) analog pathways due to its structural relationship.

Basic Information

Item	Detail
Product Name	4-(Methyl-D3-Amino)Butyric-2,2,3,3,4,4-D6 Acid Hcl
CAS No.	1219805-36-3
Molecular Formula	C5H2D9NO2·HCl
Molecular Weight	Contact for details
Synonyms	4-(Methyl-d3-amino)butyric-2,2,3,3,4,4-d6 acid hydrochloride; (3-Carboxypropyl)(methyl-d3)amine-2,2,3,3,4,4-d6 hydrochloride; 4-(N-Methyl-d3-amino)butyric-d6 acid HCl; γ-(Methyl-d3-amino)butyric-d6 acid hydrochloride; Deuterated GABA methyl ester derivative HCl salt; Methyl-d3-aminobutyric-d6 acid HCl; Stable Isotope Labeled Internal Standard for 4-Methylaminobutyric acid; [2H9]-4-(Methylamino)butanoic acid hydrochloride
EINECS	Contact for details

Quality Control

Every batch of our deuterated compounds is manufactured and tested under strict quality management protocols to ensure exceptional isotopic purity and chemical integrity, which are critical for reliable analytical results. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as isotopic enrichment (atom % D), chemical purity, and identity confirmation via spectroscopic methods. Our quality systems are designed to support GLP (Good Laboratory Practice) and cGMP (current Good Manufacturing Practice) compliant research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment and allowed to reach ambient temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Atom % D)	≥ 98.0% (by MS)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.