Description

3-Isobutyl-1-Methyl-D3-2-Pyrazinone is a deuterated derivative of a pyrazinone compound, where three hydrogen atoms are replaced with the stable isotope deuterium. This deuteration is critical for enhancing metabolic stability and is a powerful tool in drug discovery and development, particularly for pharmacokinetic and mass spectrometry studies. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and advanced analytical standards.

Application

• As a deuterated building block in the synthesis of isotopically labeled pharmaceutical compounds for drug metabolism and pharmacokinetics (DMPK) studies.
• Use as an internal standard in quantitative mass spectrometry (LC-MS/MS, GC-MS) to ensure analytical accuracy and reproducibility in bioanalytical assays.
• Intermediate in the research and development of new chemical entities (NCEs), where deuterium incorporation is used to improve the metabolic profile of lead compounds.
• Production of non-radioactive isotopic tracers for mechanistic studies in medicinal chemistry and biochemistry.
• Key starting material for the preparation of high-value specialty chemicals and advanced materials requiring isotopic labeling.

Basic Information

Product Name	3-Isobutyl-1-Methyl-D3-2-Pyrazinone
CAS No.	1219805-28-3
Molecular Formula	C9H12D3N2O
Molecular Weight	170.24 g/mol
Synonyms	1-Methyl-3-(2-methylpropyl)-1H-pyrazin-2(1H)-one-d3; 3-Isobutyl-1-methyl-1H-pyrazin-2-one-d3; 1-Methyl-3-isobutylpyrazin-2(1H)-one-d3; Deuterated 3-Isobutyl-1-methyl-2(1H)-pyrazinone; D3-3-Isobutyl-1-methylpyrazinone; Isotopically Labeled Pyrazinone; [D3]-3-Isobutyl-1-methyl-2-pyrazinone
EINECS	Contact for details

Quality Control

Our 3-Isobutyl-1-Methyl-D3-2-Pyrazinone is manufactured under strict quality systems to ensure high isotopic and chemical purity, essential for sensitive research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity (by HPLC), isotopic enrichment (by NMR/MS), and identity confirmation. We adhere to cGMP principles for advanced pharmaceutical intermediates, ensuring traceability, consistency, and reliability for your critical development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect the material from moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.