Description

Fluoxetine D5 Oxalate is a deuterated internal standard of the widely prescribed antidepressant, fluoxetine. This high-purity compound is essential for ensuring the accuracy and reliability of quantitative analytical methods. It is primarily used by pharmaceutical research and development laboratories, contract research organizations (CROs), and quality control facilities specializing in bioanalytical chemistry and pharmacokinetic studies.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard in LC-MS/MS and GC-MS methods for the precise quantification of fluoxetine and its metabolites in biological matrices (e.g., plasma, serum, urine).
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion in clinical and pre-clinical research.
• Therapeutic Drug Monitoring (TDM): Used in assays to monitor fluoxetine concentration in patient samples to optimize dosage and ensure therapeutic efficacy.
• Metabolite Identification and Profiling: Aids in the identification and study of fluoxetine metabolite structures and pathways using mass spectrometry.
• Method Development and Validation: A key reagent for developing, optimizing, and validating robust analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Forensic and Toxicology Analysis: Employed in confirmatory testing for fluoxetine in forensic and clinical toxicology laboratories.

Basic Information

Product Name	Fluoxetine D5 Oxalate
CAS No.	1219804-82-6
Molecular Formula	C17H13D5F3NO • C2H2O4
Molecular Weight	459.44 g/mol
Synonyms	Fluoxetine-d5 Oxalate; N-Methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propylamine-d5 Oxalate; (±)-Fluoxetine-d5 Oxalate; Prozac-d5 Oxalate; (RS)-Fluoxetine-d5 Oxalate; 3-(p-Trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine-d5 Oxalate
EINECS	Contact for details

Quality Control

Our Fluoxetine D5 Oxalate is manufactured under strict quality control protocols to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for identity, purity (by HPLC), isotopic purity, and other critical parameters. We support compliance with cGMP and ISO 9001 standards for research and diagnostic use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.