Description

Carbamazepine-10,11-Epoxide-D10 (Rings-D10) is a deuterium-labeled analog of the primary active metabolite of the anticonvulsant drug carbamazepine. This high-purity stable isotope-labeled compound is critical for ensuring accuracy and reliability in quantitative bioanalytical studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in advanced pharmacokinetic, metabolic, and clinical research requiring precise internal standards for mass spectrometry.

Application

• Internal Standard for LC-MS/MS: Serves as a critical deuterated internal standard for the precise quantification of carbamazepine and its metabolites in biological matrices (plasma, serum, urine) using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
• Drug Metabolism and Pharmacokinetics (DMPK): Essential for studying the metabolic pathways, bioavailability, and clearance rates of carbamazepine in preclinical and clinical research.
• Therapeutic Drug Monitoring (TDM): Enables the development and validation of highly accurate assays for monitoring carbamazepine levels in patient samples to optimize dosing and minimize toxicity.
• Forensic and Toxicological Analysis: Used in forensic laboratories for the definitive identification and quantification of carbamazepine in complex samples.
• Biomarker Research: Facilitates research into potential biomarkers related to carbamazepine therapy and its effects.
• Reference Standard for Impurity Profiling: Acts as a certified reference material for identifying and quantifying specific impurities or degradation products in carbamazepine drug substance and finished products.

Basic Information

Product Name	Carbamazepine-10,11-Epoxide-D10 (Rings-D10)
CAS No.	1219804-16-6
Molecular Formula	C15H2D10N2O2
Molecular Weight	260.34 g/mol
Synonyms	10,11-Dihydro-10,11-epoxy-5H-dibenzo[b,f]azepine-5-carboxamide-D10 (rings-D10); CBZ-E-D10; Carbamazepine 10,11-epoxide-d10; 5-Carbamoyl-5H-dibenzo[b,f]azepine-10,11-epoxide-d10; 10,11-Epoxy-10,11-dihydrocarbamazepine-d10; Deuterated Carbamazepine Epoxide; Stable Isotope Labeled Carbamazepine Metabolite
EINECS	Contact for details

Quality Control

Our Carbamazepine-10,11-Epoxide-D10 (Rings-D10) is manufactured under strict quality control protocols to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for isotopic purity (D-enrichment), chemical purity (HPLC), identity confirmation (NMR, MS), and related substances. We adhere to relevant industry standards for reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This compound is hygroscopic (moisture-sensitive); desiccate if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-enrichment)	≥98.0 atom % D
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.