Description

4-Ohpropranolol-D7 Hcl CAS NO 1219804-03-1 is a high-purity, deuterium-labeled internal standard critical for advanced analytical applications. This stable isotope-labeled compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analyses, particularly in pharmacokinetic and metabolic studies. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and forensic toxicology labs engaged in precise bioanalytical method development and validation.

Application

• Internal Standard for LC-MS/MS: Serves as a critical quantitative reference standard in liquid chromatography-tandem mass spectrometry for the analysis of propranolol and its metabolites.
• Pharmacokinetic Studies: Enables accurate tracking and quantification of drug absorption, distribution, metabolism, and excretion (ADME) in biological matrices.
• Drug Metabolism Research: Used in metabolite identification and profiling studies to understand the biotransformation pathways of propranolol.
• Forensic and Clinical Toxicology: Provides a reliable benchmark for the confirmatory analysis of propranolol in forensic and clinical samples, ensuring result integrity.
• Bioanalytical Method Development: Essential for validating robust, sensitive, and specific analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Quality Control in Pharmaceutical Manufacturing: Supports impurity profiling and assay validation of propranolol active pharmaceutical ingredients (APIs) and finished dosage forms.

Basic Information

Product Name	4-Ohpropranolol-D7 Hcl
CAS No.	1219804-03-1
Molecular Formula	C₁₆H₁₄D₇NO₃ • HCl
Molecular Weight	~312.8 g/mol (as hydrochloride salt)
Synonyms	4-Hydroxypropranolol-d7 Hydrochloride; 1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol-4-hydroxy-d7 Hydrochloride; 4-OH Propranolol-d7 HCl; Deuterated 4-Hydroxypropranolol HCl; Propranolol Metabolite-d7 Hydrochloride; 4-Hydroxypropranolol (ring-D7) Hydrochloride; [D7]-4-Hydroxypropranolol HCl
EINECS	Contact for details

Quality Control

Every batch of 4-Ohpropranolol-D7 Hcl is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data from NMR (¹H, ¹³C), Mass Spectrometry, and HPLC. Certificates of Analysis (COA) are provided with each shipment, detailing purity, isotopic enrichment, and solvent content. Our quality commitment ensures the material meets the stringent requirements for use as a certified reference material in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This compound is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.