Description

Stavudine-α,α,α,6-D4 is a deuterium-labeled analog of the nucleoside reverse transcriptase inhibitor Stavudine (d4T), specifically designed for use as an internal standard in quantitative bioanalytical methods. This high-purity, isotopically labeled compound is essential for ensuring accuracy and reliability in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in drug development and analytical research.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of Stavudine in complex biological matrices such as plasma, serum, and tissue homogenates.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in mass spectrometry-based assays to study the absorption, distribution, metabolism, and excretion (ADME) profile of Stavudine.
• Bioanalytical Method Development and Validation: Serves as a stable isotope-labeled reference to improve method robustness, accuracy, and to correct for matrix effects and instrument variability.
• Clinical Research: Supports therapeutic drug monitoring (TDM) and bioavailability/bioequivalence studies for Stavudine-containing formulations.
• Metabolite Identification: Aids in the detection and structural elucidation of Stavudine metabolites using advanced mass spectrometric techniques.

Basic Information

Product Name	Stavudine-α,α,α,6-D4
CAS No.	1219803-67-4
Molecular Formula	C10H8D4N2O4
Molecular Weight	228.24 g/mol (approx.)
Synonyms	2',3'-Didehydro-3'-deoxythymidine-d4; d4T-d4; Stavudine-d4; 1-((2R,5S)-5-(Hydroxymethyl)-2,5-dihydrofuran-2-yl)-5-methyl-2,4(1H,3H)-pyrimidinedione-1,1,3,6-d4; BMS-236216-IS; Zerit-d4 (labeled)
EINECS	Contact for details

Quality Control

Our Stavudine-α,α,α,6-D4 is manufactured under strict quality control protocols to ensure it meets the exacting standards required for analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR and HPLC, to confirm chemical identity, isotopic purity (D-enrichment), and chemical purity. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-enrichment)	≥98 atom % D
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.