Description

Citalopram-D4 Hydrobromide Salt is a high-purity, isotopically labeled internal standard critical for advanced analytical quantification. This deuterated compound is essential for ensuring accuracy and reliability in sensitive mass spectrometry-based methods, providing a stable reference point for precise measurements. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in bioanalytical studies, pharmacokinetic research, and quality control of active pharmaceutical ingredients (APIs).

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard for the precise quantification of citalopram and its metabolites in complex biological matrices like plasma, serum, and urine.
• Pharmacokinetic and Bioavailability Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and pre-clinical research.
• Forensic and Clinical Toxicology: Supports reliable analysis in forensic investigations and therapeutic drug monitoring (TDM) programs.
• Drug Metabolism Research: Facilitates the identification and quantification of metabolite profiles in in vitro and in vivo studies.
• Pharmaceutical Quality Control: Assists in the validation of analytical methods and impurity profiling for citalopram API and finished dosage forms.
• Reference Material for Method Development: Serves as a critical tool for developing, validating, and transferring robust analytical protocols in compliance with GLP/GMP guidelines.

Basic Information

Item	Details
Product Name	Citalopram-D4 Hydrobromide Salt
CAS No.	1219803-58-3
Molecular Formula	C20H17D4FN2O•HBr
Molecular Weight	Approx. 405.3 g/mol
Synonyms	1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile-d4 Hydrobromide; (+/-)-Citalopram-d4 HBr; Citalopram (phenyl-d4) Hydrobromide; 5-[(Dimethylamino)methyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-carbonitrile-d4 Hydrobromide; Lu 10-171-d4 HBr; Racemic Citalopram-d4 Hydrobromide
EINECS	Contact for details

Quality Control

Every batch of Citalopram-D4 Hydrobromide Salt is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure exceptional quality and isotopic purity. Our quality assurance protocol is designed to meet the stringent requirements of analytical reference standard applications. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing key parameters such as chemical purity, isotopic enrichment (D4), and chromatographic profile. We support compliance with GLP and GMP standards for research and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D4)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.