Description

(±)-Betaxolol-D7 Hcl (n-iso-Propyl-D7) CAS NO 1219802-92-2 is a high-purity, deuterium-labeled internal standard critical for modern analytical chemistry. This compound is essential for ensuring the accuracy and reliability of quantitative bioanalytical methods, particularly in pharmacokinetic and metabolic studies. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and regulatory testing facilities for the precise analysis of betaxolol, a β-blocker medication.

Application

• Quantitative Bioanalysis: Serves as a stable isotope-labeled internal standard for the accurate quantification of betaxolol in biological matrices (plasma, serum, urine) using LC-MS/MS and GC-MS.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables precise measurement of drug concentration over time to determine absorption, distribution, metabolism, and excretion (ADME) profiles.
• Drug Metabolism Studies: Used in metabolite identification and profiling to understand the metabolic pathways of betaxolol.
• Method Development and Validation: A critical component in developing and validating robust, regulatory-compliant analytical methods for clinical trials and quality control.
• Forensic and Doping Control Analysis: Supports the accurate detection and quantification of betaxolol in forensic toxicology and anti-doping programs.
• Reference Material for Quality Assurance: Used as a certified reference material (CRM) to calibrate equipment and ensure data integrity across laboratories.

Basic Information

Product Name	(±)-Betaxolol-D7 Hcl (n-iso-Propyl-D7)
CAS No.	1219802-92-2
Molecular Formula	C18H22D7NO3•HCl
Molecular Weight	~348.9 g/mol
Synonyms	Betaxolol-d7 Hydrochloride; 1-[4-[2-(Cyclopropylmethoxy)ethyl]phenoxy]-3-[(1-methylethyl-d7)amino]-2-propanol Hydrochloride; (±)-Betaxolol-(isopropyl-d7) Hydrochloride; Betaxolol D7 HCl; Betaxolol Internal Standard D7; DL-Betaxolol-d7 HCl; Kerlone-d7 (labeled analog)
EINECS	Contact for details

Quality Control

Every batch of (±)-Betaxolol-D7 Hcl is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure the highest standards of isotopic purity and chemical identity. Our quality commitment includes comprehensive characterization by NMR, MS, and HPLC to confirm deuterium incorporation and chemical purity. Certificates of Analysis (COA) detailing batch-specific results for assay, isotopic enrichment, and impurities are provided and traceable to in-house reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0% (chemical purity)
Isotopic Purity (MS)	≥98.0 atom % D (D7 enrichment)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.