Description

Nifedipine-D4 (2-Nitrophenyl-D4) is a deuterium-labeled analog of the widely used calcium channel blocker nifedipine, specifically labeled at the 2-nitrophenyl position. This stable isotope-labeled compound is an essential internal standard for the precise and accurate quantification of nifedipine in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, bioequivalence testing, and drug metabolism research.

Application

• Internal Standard for Bioanalysis: Critical for quantitative LC-MS/MS analysis of nifedipine in plasma, serum, and other biological fluids to ensure method accuracy and precision.
• Pharmacokinetic & Metabolism Studies: Enables reliable tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Drug Impurity Profiling & Method Development: Used as a reference standard in the development and validation of analytical methods for drug substance and product testing.
• Forensic & Clinical Toxicology: Supports the accurate measurement of nifedipine concentrations in forensic investigations or therapeutic drug monitoring.
• Stable Isotope Labeling Research: Serves as a key reagent in studies investigating isotopic effects or as a tracer in metabolic pathway research.

Basic Information

Product Name	Nifedipine-D4 (2-Nitrophenyl-D4)
CAS No.	1219798-99-8
Molecular Formula	C17H14D4N2O6
Molecular Weight	350.36 g/mol
Synonyms	Nifedipine-d4; 3,5-Dimethyl 2,6-dimethyl-4-(2-nitrophenyl-d4)-1,4-dihydropyridine-3,5-dicarboxylate; 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl-d4)-3,5-pyridinedicarboxylic acid dimethyl ester; Deuteronifedipine; Nifedipine (phenyl-d4); Bay a 1040-d4; Adalat-d4; 2-Nitrophenyl-d4 Nifedipine
EINECS	Contact for details

Quality Control

Our Nifedipine-D4 is manufactured under strict quality control protocols to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch is characterized by NMR, HPLC, and mass spectrometry to confirm identity, chemical purity, and deuterium incorporation. A comprehensive Certificate of Analysis (COA) detailing all specifications, including isotopic purity, is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This compound is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere); it is recommended to store under an inert atmosphere such as argon or nitrogen for long-term stability.

Specification

Item	Specification
Appearance	Yellow to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0% (Chemical Purity)
Isotopic Purity	≥98.0 atom % D
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.