Description

Donepezil-D4 Hydrochloride is a deuterated isotopologue of the active pharmaceutical ingredient donepezil, specifically labeled with four deuterium atoms. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical methods. It is primarily required by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical service providers for pharmacokinetic studies, bioequivalence testing, and drug metabolism research.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of donepezil and its metabolites in complex biological matrices like plasma, serum, and tissue homogenates.
• Pharmacokinetic and Bioanalytical Studies: Enables accurate measurement of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Drug Metabolism Research: Used to investigate metabolic pathways and identify metabolites without interference from the endogenous compound.
• Quality Control and Method Validation: Serves as a reference standard in the development and validation of robust analytical methods for pharmaceutical quality assurance.
• Forensic and Clinical Toxicology: Assists in the accurate determination of donepezil levels in forensic analysis and therapeutic drug monitoring.

Basic Information

Item	Detail
Product Name	Donepezil-D4 Hydrochloride
CAS No.	1219798-88-5
Molecular Formula	C24H25D4ClNO3
Molecular Weight	416.0 g/mol (approx.)
Synonyms	Donepezil-d4 HCl; 1-Benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine-d4 Hydrochloride; Aricept-d4 Hydrochloride; E2020-d4 Hydrochloride; (±)-2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl-d4]methyl]-1H-inden-1-one Hydrochloride; 2-[(1-Benzyl-4-piperidinyl-d4)methyl]-5,6-dimethoxy-1-indanone Hydrochloride
EINECS	Contact for details

Quality Control

Our Donepezil-D4 Hydrochloride is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as assay, isotopic enrichment, and impurity profile. We adhere to relevant industry standards for reference materials to guarantee reliable and reproducible performance in your laboratory.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Enrichment	≥98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.