Description

Valdecoxib-D3 is a deuterium-labeled analog of the selective COX-2 inhibitor valdecoxib, specifically designed for use as an internal standard in quantitative analytical methods. This stable isotope-labeled compound is essential for ensuring the accuracy and reliability of mass spectrometry-based analyses in pharmaceutical research and development. It is primarily utilized by analytical chemists and researchers in pharmaceutical companies, contract research organizations (CROs), and regulatory testing laboratories for pharmacokinetic studies, drug metabolism research, and bioanalytical method validation.

Application

• Internal Standard for LC-MS/MS: Serves as a critical internal standard for the precise quantification of valdecoxib in complex biological matrices such as plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in tracer studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of valdecoxib.
• Bioanalytical Method Development and Validation: Essential for developing, optimizing, and validating robust high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) methods to meet regulatory guidelines (e.g., FDA, EMA).
• Clinical Research: Supports therapeutic drug monitoring and clinical trial sample analysis to ensure data integrity.
• Pharmaceutical Quality Control: Can be employed in impurity profiling and stability-indicating assay methods for drug substance and product analysis.
• Forensic and Anti-Doping Analysis: Facilitates the accurate detection and quantification of valdecoxib in forensic toxicology and sports doping control.

Basic Information

Product Name	Valdecoxib-D3
CAS No.	1219794-90-7
Molecular Formula	C16H11D3N2O4S
Molecular Weight	317.36 g/mol
Synonyms	4-[5-Methyl-3-phenyl-4-isoxazolyl]benzenesulfonamide-d3; BEXTRA-d3; SC 65872-d3; Valdecoxib (phenyl-d3); Deuterated Valdecoxib; Valdecoxib Internal Standard; Valdecoxib-d3 (IS); [2H3]-Valdecoxib
EINECS	Contact for details

Quality Control

Our Valdecoxib-D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for chemical purity and NMR/MS for isotopic enrichment and structural confirmation, to ensure it meets the high standards required for analytical applications. Certificates of Analysis (COA) detailing batch-specific results for identity, purity (typically ≥98% chemical purity, ≥99% isotopic purity), and impurities are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 99.0 atom % D
Chemical Purity	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.