Description

(R)-2-Methyl-n-[(1E)-2,2,2-Trifluoroethylidene]Propane-2-Sulfinamide is a high-purity chiral sulfinamide building block essential for asymmetric synthesis. This compound serves as a versatile chiral auxiliary and ligand, enabling the stereoselective construction of complex molecules with high enantiomeric purity. It is a critical intermediate for researchers and process chemists in the pharmaceutical, agrochemical, and advanced material sectors developing novel active ingredients and functional compounds.

Application

• Asymmetric Synthesis: Key chiral auxiliary for the stereocontrolled addition of nucleophiles to imines and related electrophiles.
• Pharmaceutical Intermediate: Building block for the research and development of enantiomerically pure active pharmaceutical ingredients (APIs), particularly those containing trifluoromethyl groups.
• Agrochemical Synthesis: Used in the creation of chiral herbicides, fungicides, and insecticides where specific stereochemistry is required for optimal activity.
• Ligand in Catalysis: Can be utilized in the preparation of chiral ligands for transition metal-catalyzed reactions.
• Material Science Research: Intermediate for synthesizing chiral organic compounds with potential applications in liquid crystals or nonlinear optical materials.
• Academic & Process R&D: A valuable tool for methodological development in organic chemistry and scale-up process optimization.

Basic Information

Product Name	(R)-2-Methyl-n-[(1E)-2,2,2-Trifluoroethylidene]Propane-2-Sulfinamide
CAS No.	1219607-85-8
Molecular Formula	C7H12F3NOS
Molecular Weight	215.24 g/mol
Synonyms	(R)-N-[(E)-2,2,2-Trifluoroethylidene]-2-methylpropane-2-sulfinamide; (R)-2-Methyl-N-[(1E)-2,2,2-trifluoroethylidene]propane-2-sulfinamide; (R)-N-(2,2,2-Trifluoroethylidene)-2-methylpropane-2-sulfinamide; (R)-tert-Butanesulfinamide, N-[(E)-2,2,2-trifluoroethylidene]-; (R)-N-(Trifluoroethylidene)-2-methylpropane-2-sulfinamide; (R)-N-(2,2,2-Trifluoro-1-iminoethyl)-2-methylpropane-2-sulfinamide; (R)-Trifluoroacetimidoyl tert-Butyl Sulfoxide
EINECS	Contact for details

Quality Control

Our (R)-2-Methyl-n-[(1E)-2,2,2-Trifluoroethylidene]Propane-2-Sulfinamide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. Quality is verified by advanced analytical techniques including HPLC, GC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.