Description

Pazopanib-D6 is a deuterated internal standard of the multi-tyrosine kinase inhibitor Pazopanib, specifically designed for use in quantitative analytical methods. This high-purity reference material is essential for ensuring accuracy and reliability in pharmacokinetic and bioanalytical studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in drug development and therapeutic monitoring.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard for the precise quantification of Pazopanib in biological matrices (e.g., plasma, serum) using LC-MS/MS and HPLC methods.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate measurement of drug concentration over time to determine absorption, distribution, metabolism, and excretion (ADME) profiles.
• Method Development and Validation: Used as a benchmark compound to develop, optimize, and validate robust analytical assays in compliance with GLP and ICH guidelines.
• Clinical Trial Support: Facilitates reliable drug monitoring in patient samples during clinical trials for oncology treatments.
• Metabolite Identification: Aids in distinguishing drug-derived metabolites from endogenous compounds in mass spectrometry-based studies.
• Quality Control in Manufacturing: Can be employed as a reference standard for quality control testing of Pazopanib active pharmaceutical ingredient (API) and finished dosage forms.

Basic Information

Product Name	Pazopanib-D6
CAS No.	1219592-01-4
Molecular Formula	C21H17D6N5O2S
Molecular Weight	~ 443.56 g/mol
Synonyms	Pazopanib (hexadeuterated); Pazopanib-d6; 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide-d6; Votrient-d6 (deuterated); GW786034-d6; N-(4-([4-Amino-5-(2,3-dimethyl-2H-indazol-6-ylamino)pyrimidin-2-yl]methylamino)pyridin-2-yl)benzamide-d6 (alternative representation); Deuterated Pazopanib Internal Standard
EINECS	Contact for details

Quality Control

Every batch of Pazopanib-D6 is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to support its use as a certified reference material. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request and include detailed results for identity, purity (HPLC), isotopic enrichment, and residual solvents, supporting traceability and method validation.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to maintain stability and purity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (Mass Spec)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.