Description

(±)-Ethyl 2,3,3-Trifluorobutyrate CAS NO 1219589-17-9 is a high-purity fluorinated ester building block of significant interest in advanced organic synthesis. Its value lies in the strategic incorporation of fluorine atoms, which can dramatically alter the physical, chemical, and biological properties of target molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries seeking to develop novel active ingredients with enhanced metabolic stability, bioavailability, or lipophilicity.

Application

• Pharmaceutical Intermediate: Key synthon for the preparation of fluorinated active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, antivirals, and anti-cancer agents.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and pesticides where fluorine substitution improves efficacy and environmental profile.
• Liquid Crystal & Electronic Materials: Serves as a precursor for fluorinated components in liquid crystal displays (LCDs) and dielectric materials, leveraging fluorine's unique electronic properties.
• Advanced Polymer Chemistry: Employed as a monomer or modifier to introduce fluorine into polymer backbones, enhancing material properties like chemical resistance, thermal stability, and low surface energy.
• Organic Synthesis Building Block: A versatile reagent for nucleophilic substitution, reduction, and cross-coupling reactions to introduce the 2,3,3-trifluorobutyl moiety into complex molecular architectures.
• Fluorine-19 NMR Spectroscopy: Can be utilized as a standard or reference compound in 19F NMR studies due to its distinct fluorine signature.

Basic Information

Item	Details
Product Name	(±)-Ethyl 2,3,3-Trifluorobutyrate
CAS No.	1219589-17-9
Molecular Formula	C6H9F3O2
Molecular Weight	170.13 g/mol
Synonyms	Ethyl 2,3,3-trifluorobutanoate; 2,3,3-Trifluorobutanoic acid ethyl ester; DL-Ethyl 2,3,3-trifluorobutyrate; (±)-2,3,3-Trifluorobutyric acid ethyl ester; Butanoic acid, 2,3,3-trifluoro-, ethyl ester; Ethyl α,β,β-trifluorobutyrate; 1219589-17-9
EINECS	Contact for details

Quality Control

Our (±)-Ethyl 2,3,3-Trifluorobutyrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container must be kept tightly closed to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Refractive Index (n20/D)	1.360 - 1.380
Density (20°C)	1.20 - 1.30 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.