Description

Fmoc-5-Methoxy-2-Methyl-Dl-Tryptophan CAS NO 1219357-78-4 is a protected, non-natural amino acid derivative designed for solid-phase peptide synthesis (SPPS). This compound is a critical building block for researchers and manufacturers developing novel peptides with enhanced stability or specific biological activity. It is primarily utilized in pharmaceutical R&D, biotechnology, and advanced materials science for creating custom peptide sequences, peptidomimetics, and bioactive probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it serves as a key monomer for the automated, stepwise construction of custom peptide chains.
• Pharmaceutical Research & Development: Used to incorporate modified tryptophan analogs into peptide drug candidates to modulate pharmacokinetics, receptor binding, or metabolic stability.
• Bioconjugation and Probe Development: The indole moiety and methyl/methoxy substitutions make it a valuable precursor for creating fluorescent tags, affinity labels, or other functionalized biomolecules.
• Peptidomimetic Design: The 2-methyl and 5-methoxy modifications on the tryptophan side chain are used to explore structure-activity relationships and develop more drug-like peptide analogs.
• Academic and Institutional Research: Essential for fundamental studies in chemical biology, medicinal chemistry, and protein engineering.
• Contract Manufacturing (CMO/CDMO): A specified raw material for the GMP or non-GMP production of therapeutic peptides for clinical trials and commercial supply.

Basic Information

Product Name	Fmoc-5-Methoxy-2-Methyl-Dl-Tryptophan
CAS No.	1219357-78-4
Molecular Formula	C30H30N2O5
Molecular Weight	498.57 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-5-methoxy-2-methyl-DL-tryptophan; Fmoc-5-MeO-2-Me-DL-Trp-OH; (±)-N-Fmoc-5-methoxy-2-methyltryptophan; Fmoc-DL-5-Methoxy-2-methyltryptophan; 5-Methoxy-2-methyl-DL-tryptophan, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; N-α-Fmoc-5-methoxy-2-methyl-DL-tryptophan; Fmoc-5-methoxy-2-methyltryptophan (racemic); Fmoc-(5-MeO-2-Me)DL-Trp
EINECS	Contact for details

Quality Control

Our Fmoc-5-Methoxy-2-Methyl-Dl-Tryptophan is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.