Description

Fmoc-2-Amino-3-Hydroxypentanoic Acid CAS NO 1219207-99-4 is a high-purity, non-natural amino acid derivative featuring orthogonal protecting groups, making it an essential building block for advanced peptide synthesis. Its primary value lies in enabling the precise construction of complex peptide sequences, particularly for research into novel pharmaceuticals and bioactive compounds. This product is critically needed by medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and academic research sectors for drug discovery and development programs.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/tBu strategy, facilitating the assembly of complex peptides.
• Medicinal Chemistry & Drug Discovery: Used to incorporate unique structural motifs and side-chain functionalities into peptide-based drug candidates.
• Peptidomimetic Development: Serves as a precursor for creating stable, non-hydrolyzable peptide analogs with enhanced therapeutic properties.
• Bioconjugation and Labeling: The reactive carboxyl and amino groups (after deprotection) allow for site-specific conjugation with labels, tags, or other biomolecules.
• Chemical Biology Probes: Integral for synthesizing custom peptides used as tools to study protein-protein interactions and enzyme function.
• Process Development & Scale-Up: Supplied in consistent quality for transitioning from laboratory-scale research to pre-clinical and clinical manufacturing.

Basic Information

Product Name	Fmoc-2-Amino-3-Hydroxypentanoic Acid
CAS No.	1219207-99-4
Molecular Formula	C₂₁H₂₃NO₅
Molecular Weight	369.41 g/mol
Synonyms	Fmoc-Ahp-OH; Fmoc-2-Amino-3-hydroxypentanoic acid; N-(9-Fluorenylmethoxycarbonyl)-2-amino-3-hydroxypentanoic acid; (2S,3S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-hydroxypentanoic acid; Fmoc-(2S,3S)-Ahp-OH; Fmoc-L-threo-β-Hydroxyhomoleucine; Nα-Fmoc-2-amino-3-hydroxypentanoic acid; Fmoc-β-hydroxy-norvaline derivative
EINECS	Contact for details

Quality Control

Every batch of Fmoc-2-Amino-3-Hydroxypentanoic Acid is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure it meets the high-purity standards required for peptide synthesis. Our quality commitment includes full traceability and compliance with relevant guidelines for advanced pharmaceutical intermediates. A detailed Certificate of Analysis (COA) providing purity, chiral purity, and impurity profiles is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% de
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.