Description

Boc-6-Chloro-Dl-Tryptophan is a protected derivative of the non-natural amino acid 6-chloro-DL-tryptophan, where the amine group is shielded by a tert-butoxycarbonyl (Boc) protecting group. This compound is a critical building block in solid-phase peptide synthesis (SPPS) and medicinal chemistry research, enabling the controlled introduction of halogenated tryptophan analogs into peptide chains. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers for developing novel therapeutic peptides and investigating structure-activity relationships.

Application

• Peptide Synthesis Intermediate: Serves as a key protected amino acid precursor in the synthesis of complex peptides containing modified tryptophan residues.
• Medicinal Chemistry Research: Used in the design and development of new drug candidates, particularly for incorporating halogenated tryptophan motifs to modulate bioactivity and metabolic stability.
• Bioconjugation & Probe Development: Acts as a starting material for creating fluorescent probes, affinity labels, or other bioconjugates for biochemical and cellular studies.
• Academic & Institutional Research: Employed in university and institutional labs for fundamental studies in organic chemistry, peptide science, and chemical biology.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of custom peptides and specialized fine chemicals for clients.

Basic Information

Product Name	Boc-6-Chloro-Dl-Tryptophan
CAS No.	1219193-65-3
Molecular Formula	C₁₆H₁₉ClN₂O₄
Molecular Weight	338.79 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-6-chloro-DL-tryptophan; Boc-6-Cl-DL-Trp-OH; (RS)-2-((tert-Butoxycarbonyl)amino)-3-(6-chloro-1H-indol-3-yl)propanoic acid; 6-Chloro-DL-tryptophan, N-Boc-; tert-Butyl (6-chloro-1H-indol-3-yl)methylcarbamate; N-Boc-6-chlorotryptophan; DL-6-Chlorotryptophan N-Boc derivative
EINECS	Contact for details

Quality Control

Our Boc-6-Chloro-Dl-Tryptophan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and spectroscopic identification (NMR, IR, MS). A Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere, consider sealing under argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 98.0%
Optical Purity (Chiral HPLC)	DL-mixture (Racemic)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.