Description

Thalidomide-D4 is a stable isotope-labeled analog of thalidomide, where four hydrogen atoms are replaced by deuterium. This product is a critical internal standard for the precise quantitative analysis of thalidomide in complex biological matrices using advanced techniques like LC-MS/MS. It is essential for researchers and quality control laboratories in the pharmaceutical and biotechnology sectors, particularly those involved in pharmacokinetic studies, drug metabolism research, and ensuring the accuracy of bioanalytical methods. The compound is supplied with guaranteed high chemical and isotopic purity to ensure reliable and reproducible results.

Application

• Primary use as an internal standard in the quantitative bioanalysis of thalidomide via LC-MS/MS and GC-MS.
• Critical for pharmacokinetic (PK) and pharmacodynamic (PD) studies to understand drug absorption, distribution, metabolism, and excretion.
• Enables accurate drug metabolism and disposition (DMPK) research in preclinical and clinical development.
• Supports therapeutic drug monitoring (TDM) and bioequivalence studies for regulatory submissions.
• Used in forensic and clinical toxicology for the specific and sensitive detection of thalidomide.
• Facilitates impurity profiling and stability testing of pharmaceutical formulations containing thalidomide.
• Valuable in academic research investigating the mechanisms of action and teratogenicity of thalidomide and its analogs.

Basic Information

Product Name	Thalidomide-D4
CAS No.	1219177-18-0
Molecular Formula	C13H6D4N2O4
Molecular Weight	264.25 g/mol
Synonyms	(±)-Thalidomide-d4; 2-(2,6-Dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione-d4; α-Phthalimidoglutarimide-d4; N-(2,6-Dioxo-3-piperidinyl)phthalimide-d4; Kevadon-d4; Talizer-d4; Neurosedyn-d4; Contergan-d4; Isotopically Labeled Thalidomide (D4)
EINECS	Contact for details

Quality Control

Every batch of Thalidomide-D4 is manufactured and analyzed under strict quality management systems. We guarantee high chemical purity and isotopic enrichment, with specifications verified by NMR (1H, 13C), mass spectrometry, and HPLC. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, isotopic purity (D-enrichment), and solvent residue levels. Our quality commitment ensures the material meets the stringent requirements for use as a certified reference material in regulated bioanalytical laboratories.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C to maximize stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.