Description

Fmoc-γ-Methylene-Dl-Glutamic Acid CAS NO 1219174-57-8 is a protected, non-natural amino acid derivative designed for solid-phase peptide synthesis (SPPS). This compound is a critical building block for the research and development of novel peptides and peptidomimetics, offering a unique γ-methylene modification to the glutamic acid side chain. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on drug discovery and chemical biology.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of complex peptide sequences, particularly those requiring modified glutamic acid residues.
• Peptidomimetic Drug Discovery: Used to incorporate a metabolically stable γ-methylene linkage into peptide backbones, enhancing resistance to enzymatic degradation for therapeutic candidates.
• Chemical Biology Probes: Serves as a building block for creating labeled or functionalized peptides used in studying protein-protein interactions and enzyme mechanisms.
• Research on Glutamate Analogs: Enables the study of glutamate receptor pharmacology and neurotransmission by providing a structurally constrained analog of glutamic acid.
• Linker and Conjugation Chemistry: The carboxylic acid groups, when deprotected, can be used for conjugation to other molecules, surfaces, or solid supports.

Basic Information

Product Name	Fmoc-γ-Methylene-Dl-Glutamic Acid
CAS No.	1219174-57-8
Molecular Formula	C₂₂H₂₁NO₆
Molecular Weight	395.41 g/mol
Synonyms	Fmoc-γ-methylene-DL-Glu; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-γ-methylene-DL-glutamic acid; Fmoc-DL-γ-methylene-Glu-OH; (RS)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-4-methylenepentanedioic acid; Fmoc-γ-CH₂-Glu-OH; DL-2-(Fmoc-amino)-4-methylenepentanedioic acid; Fmoc-Amino-γ-methylene-glutaric Acid; Fmoc protected γ-methylene glutamic acid
EINECS	Contact for details

Quality Control

Our Fmoc-γ-Methylene-Dl-Glutamic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for peptide synthesis. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.