Description

n-Acetyl Sulfadiazine-D4 is a deuterated derivative of the sulfonamide antibiotic intermediate, n-Acetyl Sulfadiazine. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reproducibility in analytical methods. It is a critical material for pharmaceutical research and development, clinical laboratories, and contract research organizations (CROs) engaged in pharmacokinetic studies, drug metabolism research, and bioanalytical method development.

Application

• Primary use as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the quantification of sulfadiazine and its metabolites.
• Essential for pharmacokinetic and bioequivalence studies in drug development, providing precise data on drug absorption, distribution, metabolism, and excretion (ADME).
• Critical component in clinical and veterinary diagnostic assays for monitoring antibiotic levels in biological matrices like plasma, serum, and tissue.
• Used in doping control analysis and forensic toxicology to detect and confirm the presence of sulfonamide antibiotics.
• Supports environmental monitoring research for tracing pharmaceutical residues in water and soil samples.
• Facilitates metabolite identification and pathway elucidation studies in advanced pharmaceutical R&D.

Basic Information

Product Name	n-Acetyl Sulfadiazine-D4
CAS No.	1219149-66-2
Molecular Formula	C12H9D4N4O3S
Molecular Weight	281.33 g/mol
Synonyms	N-(2-Pyrimidinyl-4-D)sulfanilamide-D3, N-acetate; Sulfadiazine-D4, N-acetyl-; 4-Amino-N-(4,6-dimethyl-2-pyrimidinyl-D6)benzenesulfonamide-D3, N-acetyl-; Deuterated N-Acetylsulfadiazine; Acetylsulfadiazine-d4; Stable Isotope Labeled Sulfadiazine Acetate; Internal Standard for Sulfadiazine LC-MS
EINECS	Contact for details

Quality Control

Every batch of n-Acetyl Sulfadiazine-D4 is manufactured and tested under strict quality management systems. We guarantee high chemical purity and isotopic enrichment, supported by comprehensive analytical data including NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, isotopic purity (D-enrichment), and absence of critical unlabeled impurities. Our quality commitment ensures reliability for your most sensitive analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.