Description

Fmoc-2-Amino-4,4,4-Trifluorobutyric Acid CAS NO 1219145-37-5 is a high-purity, non-natural amino acid derivative featuring a trifluoromethyl group, protected by a fluorenylmethyloxycarbonyl (Fmoc) group on the α-amino function. This compound is a critical building block for the solid-phase peptide synthesis (SPPS) of peptides with enhanced metabolic stability, lipophilicity, and bioavailability. It is primarily utilized by pharmaceutical R&D teams, peptide manufacturers, and academic research laboratories focused on developing novel therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected amino acid for the automated synthesis of complex peptides incorporating trifluoromethylated residues.
• Pharmaceutical Research: Used in the development of peptide-based drugs where the CF3 group modulates pharmacokinetic properties such as membrane permeability and metabolic resistance.
• Peptidomimetic Design: Serves as a precursor for creating peptidomimetics and bioactive probes that mimic natural peptides with improved stability.
• Chemical Biology & Proteomics: Employed in the synthesis of labeled peptides or activity-based probes for studying protein-protein interactions and enzyme function.
• Agrochemical Research: Potential application in the design of novel bioactive peptides for crop protection agents.
• Material Science: Can be used to synthesize fluorinated peptides for creating specialized surfaces or biomaterials with unique properties.

Basic Information

Item	Detail
Product Name	Fmoc-2-Amino-4,4,4-Trifluorobutyric Acid
CAS No.	1219145-37-5
Molecular Formula	C19H16F3NO4
Molecular Weight	379.33 g/mol
Synonyms	Fmoc-2-Amino-4,4,4-trifluorobutanoic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-amino-4,4,4-trifluorobutanoic Acid; 2-[(9-Fluorenylmethoxycarbonyl)amino]-4,4,4-trifluorobutanoic Acid; Fmoc-4,4,4-trifluoro-DL-norvaline; Fmoc-Tfb-OH; Fmoc-2-Amino-4,4,4-trifluorobutyrate; N-Fmoc-2-amino-4,4,4-trifluorobutyric acid
EINECS	Contact for details

Quality Control

Our Fmoc-2-Amino-4,4,4-Trifluorobutyric Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis where applicable, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation and maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.