Description

Anhydro Vinblastine-D3 Disulfate Salt is a high-purity, deuterium-labeled analog of the potent vinca alkaloid, vinblastine. This stable isotope-labeled compound is essential for use as an internal standard in quantitative bioanalytical methods, ensuring unparalleled accuracy and reliability in pharmacokinetic and metabolic studies. It is a critical material for pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in the development and quality control of oncology therapeutics.

Application

• LC-MS/MS Internal Standard: Primary application as a quantitative internal standard in Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) for the precise measurement of vinblastine and its metabolites in biological matrices.
• Pharmacokinetic (PK) Studies: Enables accurate determination of drug concentration-time profiles, bioavailability, and half-life during preclinical and clinical development of vinblastine-based therapies.
• Metabolite Identification & Profiling: Used in high-resolution mass spectrometry to aid in the structural elucidation and quantification of vinblastine metabolites.
• Bioanalytical Method Development & Validation: Serves as a critical reference material for developing, optimizing, and validating robust analytical methods compliant with FDA, EMA, and ICH guidelines.
• Drug Metabolism and Pharmacokinetics (DMPK): Supports critical DMPK studies to understand the absorption, distribution, metabolism, and excretion (ADME) of vinblastine.
• Quality Control & Assurance: Employed in the quality control testing of active pharmaceutical ingredients (APIs) and finished drug products to ensure batch-to-batch consistency and potency.

Basic Information

Item	Details
Product Name	Anhydro Vinblastine-D3 Disulfate Salt
CAS No.	1219117-51-7
Molecular Formula	C46H55D3N4O10 • H2SO4
Molecular Weight	Contact for details
Synonyms	Vinblastine-d3 Anhydro Disulfate; 3',4'-Didehydro-4'-deoxy-8'-norvinblastine-d3 Disulfate Salt; Deoxyvinblastine-d3 Disulfate; Catharanthine-d3-Vindoline Coupling Product Disulfate; Deuterated Vinblastine Internal Standard; [2H3]-Anhydrovinblastine Disulfate; Stable Isotope Labeled Vinblastine Analog
EINECS	Contact for details

Quality Control

Every batch of Anhydro Vinblastine-D3 Disulfate Salt is manufactured and analyzed under strict quality systems. We provide comprehensive analytical data to support its use in regulated environments, including certificates of analysis (COA) detailing isotopic purity, chemical purity, and identity confirmation via advanced spectroscopic techniques. Our quality commitment ensures consistency and reliability for your most critical analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (H-NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (MS)	≥ 98 atom % D
Chemical Purity	≥ 90% (by HPLC)
Water Content (KF)	≤ 5.0 %
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.