Description

n-Me-D-His-Ome·Hcl CAS NO 1219090-51-3 is a protected derivative of the amino acid histidine, specifically the D-isomer with N-methylation and a methyl ester group, presented as its hydrochloride salt. This compound is a critical building block in the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control and enhanced metabolic stability for advanced research applications. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic institutions engaged in the development of novel therapeutic agents, diagnostic tools, and biochemical probes.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate modified histidine residues into peptide sequences.
• Bioconjugation & Probe Development: Serves as a precursor for creating labeled peptides or affinity probes for biochemical and diagnostic applications.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore the impact of histidine modification on peptide bioactivity and stability.
• Academic & Institutional Research: Utilized in university and government labs for fundamental studies in biochemistry, enzymology, and molecular biology.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of custom peptides and novel chemical entities.

Basic Information

Product Name	n-Me-D-His-Ome·Hcl
CAS No.	1219090-51-3
Molecular Formula	C9H16N3O2·HCl
Molecular Weight	231.70 g/mol (Free base: 198.25 g/mol)
Synonyms	N-Methyl-D-histidine methyl ester hydrochloride; D-N(τ)-Methylhistidine methyl ester HCl; Methyl (2R)-3-(1-methyl-1H-imidazol-5-yl)-2-(methylamino)propanoate hydrochloride; (R)-Methyl 2-(methylamino)-3-(1-methyl-1H-imidazol-5-yl)propanoate hydrochloride; D-1-Methylhistidine methyl ester hydrochloride; D-N-Methylhistidine methyl ester hydrochloride; Protected D-Histidine derivative; D-His(1-Me)-OMe·HCl
EINECS	Contact for details

Quality Control

Our n-Me-D-His-Ome·Hcl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to confirm stereochemical integrity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, assay, and impurity profiles. We support compliance with relevant guidelines for research-grade chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.