Description

2-(3,3-Difluorocyclobutyl)Acetonitrile is a versatile fluorinated building block of significant interest in advanced organic synthesis. Its value lies in the unique reactivity of the nitrile group and the steric and electronic properties imparted by the difluorocyclobutyl moiety, enabling the construction of complex molecular architectures. This intermediate is particularly sought after by research and development teams in the pharmaceutical and agrochemical sectors for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, protease inhibitors, and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the introduction of fluorine atoms can enhance biological activity, metabolic stability, and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis and transition metal catalysis.
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced organic materials with tailored properties such as thermal stability, chemical resistance, and unique optical characteristics.
• Chemical Biology Probes: Utilized to create fluorinated analogs of biomolecules for use in mechanistic studies and diagnostic applications.

Basic Information

Product Name	2-(3,3-Difluorocyclobutyl)Acetonitrile
CAS No.	1219019-02-9
Molecular Formula	C6H7F2N
Molecular Weight	131.12 g/mol
Synonyms	2-(3,3-Difluorocyclobutyl)ethanenitrile; (3,3-Difluorocyclobutyl)acetonitrile; 3,3-Difluorocyclobutan-1-ylacetonitrile; 2-(3,3-Difluorocyclobutyl)acetonitrile; Acetonitrile, 2-(3,3-difluorocyclobutyl)-; 1219019-02-9
EINECS	Contact for details

Quality Control

Our 2-(3,3-Difluorocyclobutyl)Acetonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to rigorous analytical testing, including NMR, HPLC, and GC analysis, to confirm identity and quantify purity and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. For long-term storage, consider maintaining under an inert atmosphere to preserve quality.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.