Description

4-(Benzyloxycarbonylamino)-2-Fluorophenylboronic Acid, Pinacol Ester is a sophisticated, high-purity boronic ester derivative, a critical protected intermediate in modern synthetic chemistry. Its primary value lies in enabling precise Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. This compound is essential for researchers and process chemists in pharmaceutical R&D and fine chemical synthesis, where it serves as a key building block for developing active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Pharmaceutical Intermediate: A crucial protected building block for the synthesis of novel drug candidates, particularly in constructing fluorinated biaryl scaffolds common in kinase inhibitors and other targeted therapies.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a stable, air- and moisture-tolerant boronate reagent for palladium-catalyzed carbon-carbon bond formation, offering superior handling compared to free boronic acids.
• Medicinal Chemistry & Drug Discovery: Enables the rapid exploration of structure-activity relationships (SAR) by facilitating the introduction of fluorinated aromatic segments into lead compounds.
• Fine Chemical Synthesis: Used in the multi-step synthesis of complex organic molecules, agrochemicals, and advanced materials requiring specific fluorinated aromatic architectures.
• Chemical Biology & Proteolysis-Targeting Chimeras (PROTACs): Acts as a versatile linker component in the construction of bifunctional molecules for targeted protein degradation research.
• Material Science Research: Employed in the development of organic electronic materials, ligands for catalysts, and specialty polymers where fluorinated aromatic units are desired.

Basic Information

Product Name	4-(Benzyloxycarbonylamino)-2-Fluorophenylboronic Acid, Pinacol Ester
CAS No.	1218791-13-9
Molecular Formula	C20H23BFNO4
Molecular Weight	371.21 g/mol
Synonyms	N-[(Benzyloxy)carbonyl]-2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline; 2-Fluoro-4-[(phenylmethoxy)carbonyl]amino]benzeneboronic Acid Pinacol Ester; 4-(N-Cbz-amino)-2-fluorophenylboronic Acid Pinacol Ester; 4-(Benzyloxycarbonylamino)-2-fluorobenzeneboronic Acid Pinacol Ester; 2-Fluoro-4-[[(benzyloxy)carbonyl]amino]phenylboronic Acid Pinacol Ester; Cbz-Protected 2-Fluoro-4-boronic Acid Pinacol Ester Aniline; CAS 1218791-13-9
EINECS	Contact for details

Quality Control

Our 4-(Benzyloxycarbonylamino)-2-Fluorophenylboronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles. Our production adheres to cGMP principles where applicable, ensuring consistent quality and traceability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed in a dry environment to minimize moisture uptake and ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Assay	≥95.0% (by NMR)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.