Description

2-Butoxy-5-(Trifluoromethyl)Pyridine-3-Boronic Acid is a high-value organoboron building block, specifically a pyridine-substituted boronic acid, essential for modern synthetic chemistry. Its core value lies in enabling the precise construction of complex molecules through robust cross-coupling reactions, such as the Suzuki-Miyaura reaction. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing trifluoromethylpyridine motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the pyridine and trifluoromethyl groups contribute to biological activity.
• Material Science Research: Serves as a building block for creating novel organic electronic materials, ligands for catalysts, and metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: Primarily employed in Suzuki-Miyaura cross-coupling to form biaryl and heterobiaryl carbon-carbon bonds with high efficiency and selectivity.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and inhibitors for target identification and validation in drug discovery.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis organizations (CSOs) and CDMOs producing bespoke compounds for client projects.

Basic Information

Item	Details
Product Name	2-Butoxy-5-(Trifluoromethyl)Pyridine-3-Boronic Acid
CAS No.	1218790-64-7
Molecular Formula	C₁₀H₁₃BF₃NO₃
Molecular Weight	263.02 g/mol
Synonyms	2-Butoxy-5-(trifluoromethyl)pyridine-3-boronic acid; 3-Borono-2-butoxy-5-(trifluoromethyl)pyridine; 5-(Trifluoromethyl)-2-butoxypyridine-3-boronic acid; 2-n-Butoxy-5-trifluoromethylpyridine-3-boronic acid; [2-Butoxy-5-(trifluoromethyl)-3-pyridyl]boronic acid; 2-Butoxy-5-trifluoromethyl-3-pyridineboronic acid; Boronic acid, B-[2-butoxy-5-(trifluoromethyl)-3-pyridinyl]-
EINECS	Contact for details

Quality Control

Every batch of 2-Butoxy-5-(Trifluoromethyl)Pyridine-3-Boronic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive cross-coupling applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and MS are available for each lot. Our quality commitment aligns with cGMP principles for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.