Description

2-Borono-5-Trifluoromethylbenzamide is a high-value, multi-functional chemical building block featuring both a boronic acid and a benzamide group. This compound is essential for advanced organic synthesis, particularly in cross-coupling reactions like the Suzuki-Miyaura reaction, enabling the efficient construction of complex molecular architectures. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Research: Used in creating novel herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Material Science: Serves as a monomer or cross-linking agent in the development of advanced polymers, liquid crystals, and organic electronic materials.
• Suzuki-Miyaura Cross-Coupling: The boronic acid functionality makes it an ideal partner for palladium-catalyzed cross-coupling to form biaryl and heterobiaryl structures, a cornerstone of modern medicinal chemistry.
• Chemical Biology & Proteomics: Can be employed as a warhead or linker in the design of activity-based probes (ABPs) and covalent inhibitors.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific, high-purity building blocks.

Basic Information

Product Name	2-Borono-5-Trifluoromethylbenzamide
CAS No.	1218790-55-6
Molecular Formula	C8H7BF3NO2
Molecular Weight	217.96 g/mol
Synonyms	5-(Trifluoromethyl)-2-carbamoylphenylboronic acid; 2-Carbamoyl-5-(trifluoromethyl)phenylboronic acid; 2-Borono-5-(trifluoromethyl)benzamide; (2-Carbamoyl-5-(trifluoromethyl)phenyl)boronic acid; B-[2-Carbamoyl-5-(trifluoromethyl)phenyl]boronic acid
EINECS	Contact for details

Quality Control

Every batch of 2-Borono-5-Trifluoromethylbenzamide is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and cGMP manufacturing. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments. Our quality commitment supports compliance with global regulatory frameworks, including REACH and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.