Description

2-Chloro-4-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile is a high-purity boronic ester derivative, a critical building block in modern synthetic chemistry. Its value lies in enabling efficient, selective cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This advanced intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing biaryl structures found in drug candidates.
• Agrochemical Synthesis: Used to create novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science Research: Serves as a building block for organic electronic materials, such as OLEDs and semiconductors.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands and organometallic catalysts.
• Chemical Biology Probes: Utilized to synthesize labeled compounds and probes for biochemical and diagnostic applications.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and scaled-up processes.

Basic Information

Product Name	2-Chloro-4-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile
CAS No.	1218790-13-6
Molecular Formula	C13H14BClFNO2
Molecular Weight	281.52 g/mol
Synonyms	2-Chloro-4-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile; 5-Cyano-2-chloro-4-fluorophenylboronic acid pinacol ester; (5-Cyano-2-chloro-4-fluorophenyl)boronic acid pinacol ester; 2-Chloro-4-fluoro-5-(pinacolatoboryl)benzonitrile; Benzonitrile, 2-chloro-4-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 1218790-13-6; PINACOL 2-CHLORO-4-FLUORO-5-CYANOPHENYLBORONATE
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high purity and batch-to-batch consistency suitable for demanding R&D and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere to maintain stability and prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.