Description

2-(Trifluoromethoxy)-Dl-Phenylalanine is a fluorinated derivative of the amino acid phenylalanine, characterized by the introduction of a trifluoromethoxy group. This modification imparts unique physicochemical properties, making it a valuable non-natural amino acid building block for advanced research and development. It is primarily utilized by pharmaceutical and agrochemical R&D teams in the synthesis of novel active compounds. The compound is supplied as a high-purity intermediate to support innovation in drug discovery and specialty chemical applications.

Application

• Pharmaceutical Intermediate: A key chiral building block for the research and synthesis of novel active pharmaceutical ingredients (APIs), particularly in metabolic and central nervous system (CNS) drug discovery.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides, where the trifluoromethoxy group can enhance biological activity and environmental stability.
• Peptide Chemistry: Incorporated into custom peptides and peptidomimetics to study structure-activity relationships (SAR) and modulate peptide stability, lipophilicity, and receptor binding.
• Chemical Biology Probe: Serves as a tool compound for labeling, imaging, or mechanistic studies in biochemical and cellular assays.
• Material Science: Potential monomer or precursor for specialty polymers and advanced materials requiring fluorinated components for specific performance characteristics.

Basic Information

Product Name	2-(Trifluoromethoxy)-Dl-Phenylalanine
CAS No.	1218228-20-6
Molecular Formula	C10H10F3NO3
Molecular Weight	249.19 g/mol
Synonyms	DL-2-(Trifluoromethoxy)phenylalanine; (RS)-2-Amino-3-[2-(trifluoromethoxy)phenyl]propanoic acid; 2-(Trifluoromethoxy)phenylalanine, DL-; α-Amino-2-(trifluoromethoxy)benzenepropanoic acid; (±)-2-(Trifluoromethoxy)phenylalanine; 2-TFMPhe; OCF3-Phe
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethoxy)-Dl-Phenylalanine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR) to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) documenting all critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.