Description

Dextrorphan-D3 is a deuterium-labeled analog of the NMDA receptor antagonist dextrorphan, a key metabolite of dextromethorphan. This stable isotope-labeled compound is specifically designed for use as an internal standard in quantitative bioanalytical methods, ensuring unparalleled accuracy and reliability in pharmacokinetic and metabolic studies. It is an essential tool for pharmaceutical R&D, clinical research, and forensic toxicology laboratories requiring precise measurement of dextrorphan or dextromethorphan levels in complex biological matrices.

Application

• Internal Standard for LC-MS/MS: Primary application as a high-purity internal standard in liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the quantification of dextrorphan and dextromethorphan.
• Pharmacokinetic Studies: Enables accurate determination of drug concentration-time profiles, bioavailability, and metabolic clearance rates in preclinical and clinical research.
• Metabolite Profiling: Used in drug metabolism and disposition (DMPK) studies to track and quantify the formation of dextrorphan from its parent drug.
• Forensic and Clinical Toxicology: Supports reliable analysis in toxicology screenings for overdose cases, compliance monitoring, and post-mortem investigations.
• Method Development and Validation: Critical for developing, optimizing, and validating robust bioanalytical assays according to FDA, EMA, and ICH guidelines.
• Stable Isotope Dilution Analysis (SIDA): Employed in SIDA protocols to correct for matrix effects, ionization suppression, and sample preparation losses, ensuring high data integrity.

Basic Information

Product Name	Dextrorphan-D3
CAS No.	1217978-17-0
Molecular Formula	C17H20D3NO
Molecular Weight	260.39 g/mol
Synonyms	(+)-3-Hydroxy-N-methylmorphinan-D3; Dextrorphan (phenyl-D3); 17-(Methyl-d3)-9α,13α,14α-morphinan-3-ol; Dextrorphan-d3; (+)-Dextrorphan-D3; Dextrorphan (trideuterated); Dextrorphan Internal Standard; NMDA receptor antagonist metabolite-D3
EINECS	Contact for details

Quality Control

Our Dextrorphan-D3 is manufactured under strict quality systems to meet the exacting standards of analytical and pharmaceutical research. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and MS, to confirm structural identity, isotopic purity (D-enrichment ≥98%), and chemical purity (typically ≥95% by HPLC). A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing batch-specific results. We support compliance with GMP/GLP principles for research use.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. The product is light-sensitive (store away from light). For long-term storage, keep the container sealed in a dry, cool environment. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Chemical Purity (NMR)	Consistent with structure
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.