Description

Ivabradine-D3 is a deuterated isotopologue of the selective If channel inhibitor Ivabradine, specifically labeled with three deuterium atoms. This stable isotope-labeled compound is an essential internal standard for the precise and accurate quantification of Ivabradine in complex biological matrices using advanced analytical techniques. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, bioequivalence testing, and drug metabolism research.

Application

• Internal Standard for LC-MS/MS Analysis: Critical for the quantitative bioanalysis of Ivabradine in plasma, serum, and other biological samples, ensuring method accuracy and reproducibility.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used to track the absorption, distribution, metabolism, and excretion (ADME) profile of the parent drug in preclinical and clinical research.
• Bioequivalence and Bioavailability Testing: Enables reliable comparison between different formulations of Ivabradine in regulatory submission studies.
• Pharmacological Research: Supports investigative studies on heart rate reduction mechanisms without interfering with the assay due to its near-identical chemical behavior.
• Quality Control in Pharmaceutical Manufacturing: Can be utilized in validated analytical methods to monitor the active pharmaceutical ingredient (API) during production.

Basic Information

Item	Detail
Product Name	Ivabradine-D3
CAS No.	1217977-70-2
Molecular Formula	C27H33D3N2O5
Molecular Weight	468.59 g/mol (approx.)
Synonyms	Ivabradine-d3; (3-{3-[(3R,4S)-1,3,4,5-Tetrahydro-7,8-dimethoxy-3-[3-[(2S)-1,4,5,6-tetrahydro-4-methyl-6-oxo-2-pyrimidinyl]phenyl]-2-benzazepin-4-yl]propyl}-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-2-one)-d3; S 16257-d3; Procoralan-d3; Coralan-d3; Corlentor-d3; Stable Isotope Labeled Ivabradine
EINECS	Contact for details

Quality Control

Our Ivabradine-D3 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic methods, including NMR, HPLC, and mass spectrometry, to confirm identity, isotopic enrichment (≥98 atom % D), and chemical purity (typically ≥95%). A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For short-term use, store at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 95%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.